Chapter 11: Immunotherapy Flashcards Preview

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Flashcards in Chapter 11: Immunotherapy Deck (13)
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1
Q

Adaptive Immune System

A

Requires time for development
Immunological Memory
Cytokines
Recognizes specific peptides

2
Q

Macrophages

A

Innate Immune System

Activated by pro-inflammatory cytokines from necrotic cells
Reactive oxygen Species(ROS)
Phagocytosis and ADCC

3
Q

NK

A

Recognize non-self tumor cells expressing lower levels of histocompatability proteins
ADCC

4
Q

APCs

A

Antigen Presenting Cells

5
Q

APC Macrophage and DC

A

Recognize tumor associated antigens as foreign

6
Q

APC primed B cells

A

Antibodies against tumor antigens

ADCC

7
Q

APC Primed Tcx Cells

A

Recognize tumor antigens on transformed cells as NON-SELF

Cytotoxicity

8
Q

Cytotoxic T Cell Killing

A

Cancer cells often down-regulate MHC1 to avoid being killed

9
Q

B Cells

A

Produce specific antibodies for opsonization (flagging)

10
Q

ADCC

A

Antibody Dependent Cellular Cytotoxicity

Mainly macrophage and NK

11
Q

T Cells

A

Recognize non-self peptides in groove of MHC molecules on surface of cells

12
Q

Two ways tumor can be recognized by immune system

A
  1. Altered Self Peptides

2. Over expression of MHC

13
Q

Innate Immune System

A

Quick Responders

Recognizes stress on cancer cells, pattern PAMPS, and abs on cells