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A - Pharmacy COPY > Chapter 10 - Muscoloskeletal System > Flashcards

Chapter 10 - Muscoloskeletal System Flashcards

1
Q

What is baclofen?

A

centrally acting muscle relaxant

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2
Q

What is the MOA of NSAIDs?

A

Inhibition of cyclo-oxegenase enzymes - result in inhibition of prostaglandin synthesis.

Selectivity for COX enzymes vary, Those more selective for COX2 are associated with less GI intolerance

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3
Q

Which NSAID is associated with the least side-effects?

A

Ibuprofen

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4
Q

What is tiaprofenic acid?

A

NSAID

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5
Q

What drug class does indometacin belong to?

A

NSAID

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6
Q

What drug class does mefenamic acid belong to?

A

NSAID

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7
Q

What side-effect has been reported with mefenamic acid, which would require discontinuation?

A

Diarrhoea and haemolytic anaemia

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8
Q

What class of drug does meloxicam belong to?

A

NSAID

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9
Q

Which NSAIDs have long duration of action which means it can be administered as a OD regimen?

A

Piroxicam

Tenoxicam

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10
Q

Which NSAID is associated with more GI side-effects and associated with more frequent skin reactions?

A

Piroxicam

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11
Q

Which NSAID is licensed for the treatment of migraines?

A

Tolfenamic acid

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12
Q

Parecoxib - selective COX2 inhibitor or non-selective COX inhibitor?

A

selective COX 2 inhibitor

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13
Q

What are your selective COX2 inhibitors?

A

Parecoxib
Celecoxib
etoricoxib

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14
Q

Which NSAIDs are licensed for use for the relief of dental/orofacial pain and are able to be prescribed by dentists according to the dental formulary?

A

Ibuprofen and diclofenac

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15
Q

High doses of which 2 NSAIDs have been associated with an increased risk of thrombotic events?

A

Diclofenac (150mg daily) and ibuprofen (2.4g daily)

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16
Q

Which 3 NSAIDs are associated with the highest risk of serious upper GI side effects?

A

Piroxicam
Ketoprofen
ketorolac

17
Q

Which NSAID has been shown to be least associated with serious upper GI side-effects?

A

Ibuprofen

18
Q

Why should NSAIDs be avoided or are cautioned in people with asthma?

A

Risk of bronchospasm with NSAIDs - may therefore exacerbate or worsen asthma

A - Pharmacy COPY (35 decks)

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