Chapter 1 - Proton-pump Inhibitors

Question 1

What is the MOA of PPIs?

Answer 1

specific inhibitor of the acid pump in the parietal cell. Rapidly acting and provides control through reversible inhibition of gastric acid secretion with once daily dosing.

Omeprazole is a weak base and is concentrated and converted to the active form in the highly acidic environment of the intracellular canaliculi within the parietal cell, where it inhibits the enzyme H+ K+-ATPase - the acid pump. This effect on the final step of the gastric acid formation process is dose-dependent and provides for highly effective inhibition of both basal acid secretion and stimulated acid secretion

Question 2

Which two electrolytes do you need to keep an eye out when someone is on long term PPIs?

Answer 2

Sodium - hyponatraemia

Magnesium - hypomagnasaemia