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Flashcards in Ch 40 Deck (14)
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1
Q

What is the prototype aminoglycoside

A

Gentamicin

2
Q

What are the Pharmacotherapeutics of gentamicin

A

Treats serious infections

3
Q

What are contraindications of gentamicin

A

Hypersensitivity
Pregnancy
Lactation

4
Q

What are adverse effects of gentamicin

A

Neurotoxicity
Nephrotoxicity
Ototoxicity
Neuromuscular blockade

5
Q

What are drug interactions of gentamicin

A
Acylxlovir
Amphotericin B
Cephalothin
Cisplatin
Cyclosporine
Loop diuretics 
Prostaglandin synthetase inhibitors
Vancomycin
6
Q

What are core pt variables regarding gentamicin

A

Past medical history and any kidney problems

Ototoxicity to fetus, assess pregnancy status

7
Q

How can one maximize therapeutic effects of gentamicin

A

Make sure that patients receive the full course as prescribed at around the clock intervals
Do not give at the same time as extended penicillin

8
Q

How can one minimize therapeutic effects of gentamicin

A

Maintain Blood levels of gentamicin within a therapeutic margin that is very narrow.
Monitor for signs of Ototoxicity and nephrotoxicity

9
Q

Gentamicin has very little effect on what type of organisms

A

Anaerobic microbes

10
Q

What are lincosamides

A

They are very toxic drugs

Their use must be monitored and limited to situations with infections by bacteria with known sensitivity

11
Q

What is the prototype lincosamides

A

( cleocin, cleocin pediatric)

12
Q

What are the Pharmacotherapeutics of clindamycin

A

It treats aerobic gram positive cocci

It treats several anaerobic gram negative and gram positive organisms

13
Q

What does clindamycin do

A

Suppresses protein synthesis

14
Q

What are aminoglycosides

A

They have been used since 1944
They are effective in treating severe infections
There us is limited due to there risk for adverse effects