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Flashcards in cancers Deck (19)
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1
Q

CML

A

myeloproliferative disorder

pluripotent stem cell

9:22, BCR-ABL - Ph22, P210

imatinibi

basophila

chronic - accelerated (10-20% blasts) - blast crisis (AML or ALL)

2
Q

PV

A

JAK2 (crhom 9)

ruxolitinib

hypervisc syndrome with decreased EPO

prolif phase - spent phase - post poly myelofibroisis - AML(2%)

3
Q

primary myelofibrosis

A

megakaryocyte cancer

JAK2, calreticulin, MPL

tear drop RBC

treat with ruxolitinib

4
Q

essential thormbocytosis

A

megakaryocyte cnacer

JAK2, calreticulin, MPL

erythromelagia = hands and feet = red

5
Q

mastocytosis

A

C-Kit mutation

uticaria pigmentosa

6
Q

AML

A

t(15:17) = promyolcytic leukemia = ATRA, risk of DIC

auer rods = myeloid blasts

IP: CD34+, 13+, 33+, 117+, TdT-

7
Q

ALL

A

childhood

bone pain

may or may not see blasts in blood

TdT+, SIg-

t(9:22)-Ph+, t(4:11), t(12;21)

hyperdiploidy (51-65) = good prog

8
Q

CLL/SLL

A

post germ center memory B cell

smudge cells

CD19+, 20+, 5+, 10-, SiG+

mutated IgVh gene = good prog

treat when symptomatic

transformations: richer (diffsue large B cell lymphoma), polymorphocytic (larger cells in circ)

9
Q

Hairy cell

A

post germ center B cells

fried egg, reticulin fibrosis

CD 19+, 20+, 5-, 10-, SIg+

CD11c+, 25+, 103+, annexin A+

BRAF mutation

spleen involvemnt always

10
Q

follicular lymphoma

A

germ center B cells

t(14:18) = overexpress BCL2

no tingible body macs

CD 19+, 20+, 5-, 10+, SIg+

11
Q

Diffuse large B cell lymphoma

A

centroblasts (in GC) or extrafolliuclalr B lymphoblasts (more aggressive)

extranodal presentation

aggressive

CD 19+, 20+, 5-, 10+/- (could be the same as follicular lymphoma but can tell by morphology)

12
Q

plasma cell myeloma

A

CRAB (inc Ca, renal probl (bence jones prot), anemia, bone lesions

rouleaux formation

paraprotien

autologous SC transplant

MGUS - 1% transform each year

13
Q

Burkit lymphoma

A

early GC b cell

endemic, sporadic (US), HIV assoicated

EBV association

tingible body macs = starry sky pattern

t(8;14), t(2:8), t(8:22)

C-MYC

CD 19+, 20+, 5-, 10+, SIg+, TdT- (tells you its not ALL or AML)

fastest growing

14
Q

mantle cell lymphma

A

pre GC B cell (naive B cell)

CD 19+, 20+, 5+, 10-, SIg+,

cyclin D1+

t(11:14)

15
Q

mycosis fungiodes

A

T cell neo

patch-plaque- nodule

pautrer microabscesses

sezary syndrome - circulating lymphoid cells in blood

cerebraform nuc on smear

16
Q

adult T cell lekumia/lymphoma

A

HTLV1 DNA test to diag

flower nuc on smear

17
Q

anaplastic large T cell lymphoma

A

CD30+

t(2:5)

multilobated nucs in horse shoe

18
Q

Hodgkin lymphoma

A

young adults

reed stern cells (owl eyes)

A symptoms (LAD, splenomegaly), B symptoms (fever, night sweats, weight loss)

CD 15+, 30+, 20-, Ig-

NF-kB acitavtion

nodular sclerosis (fibrous tissue), mixed cellularity (no fib), lymphocyte depletion, lymphocyte rich (rare)

19
Q
A