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Cancer (OSI type) > Cancer Drugs > Flashcards

Cancer Drugs Flashcards

1
Q

[Antimetabolite]

What is the MOA of 5-FU

A

inhibit thymidylate synthase

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2
Q

Drug that cause hemorrhagic cystitis

A

Cyclophosphamide

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3
Q

Drug the cause cardiomyopathy

A

Doxorubicin

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4
Q

Chemo drugs that inhibit S-phase

A

CHEM 66 FU

Cytarabine
Hydroxyurea
Etoposide
Methotrexate
6-mercaptopurine
6-thioguanine
5-FU
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5
Q

Microtubule inhibitors

A

Vinblastine
Vincristine
Paclitaxel

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6
Q

Regimen for HL

A

ABVD

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7
Q

Regimen for NHL

A

CHOP

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8
Q

FOLFIRI, FOLFOX regimen is used for

A

Colorectal CA

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9
Q

Rescue agent for cisplatin

A

Amifostine

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10
Q

Rescue agent for cisplatin

A

Amifostine

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11
Q

[Cancer pain]

First line pain medication

A

Non-opioids

Aspirin, Paracetamol

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12
Q

[Cancer pain]

pain persisting or increasing despite non-opioid use

A
  1. Opioid - Codeine
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13
Q

[Cancer pain]

Pain persisting despite codeine

A

Add strong opioids such as morphine until the patient is free of pain

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14
Q

[Cancer pain]

for children, how many steps in the ladder is recommended

A

2 steps only

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15
Q

Drug that inhibits didydroorotate dehydrogenase in pyrimidine synthesis

A

Leflunomide

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16
Q

Drug that inhibits thymidylate synthase

A

5-FU

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17
Q

Drug that inhibits de novo purine synthesis

A

6MP

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18
Q

Drugs that inhibit inosine monophosphate dehydrogenase

A

Mycophenolate and rivabirin

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19
Q

Drug that inhibits ribonucleotide reductase

A

Hydroxyurea

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20
Q

Drug that inhibit dihydrofolate reductase in humans

A

Methotrexate

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21
Q

Drug that inhibit dihydrofolate reductase in bacteria

A

trimethoprim

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22
Q

Drug that inhibit dihydrofolate reductase in protozoa

A

Pyrimethamine

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23
Q

Drug that inhibits topoisomerase I

A
  1. Irinotecan

2. Topotecan

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24
Q

Drug that inhibits topoisomerase II

A
  1. Etoposide

2. Teniposide

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25
Q

[Cancer Treatment modalities]

drug therapy is administered as the primary treatment

A

Primary Induction Therapy

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26
Q

[Cancer Treatment modalities]

use of chemotherapy in patients with localized cancer before performing local therapy

A

Neoadjuvant therapy

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27
Q

[Cancer Treatment modalities]

chemotherapy done after local treatment procedures to reduce the risk of local and systemic recurrence

A

Adjuvant chemotherapy

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28
Q

[Cancer Regimen]

ABVD

A

Hodgkin

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29
Q

[Cancer Regimen]

CHOP

A

Non-Hodgkin lymphoma

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30
Q

[Cancer Regimen]

GnRH agonist used for prostate CA

A

Leuprolide

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31
Q

[Cancer Regimen]

GnRH antagonist used to treat prostate CA

A

Abarelix

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32
Q

[Rescue Therapy]

Methotrexate

A

Leucovorin

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33
Q

[Rescue Therapy]

Cyclophosphamide

A

MESNA

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34
Q

[Rescue Therapy]

Doxorubicin

A

Dexrazoxane

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35
Q

[Rescue Therapy]

Cisplatin

A

Amifostine

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36
Q

[Alkylating agent]

Used for advanced colon and pancreatic cancer

A

Oxaliplatin

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37
Q

[Alkylating agent]

What are the side effects of cisplatin

A
  1. Acoustic nerve damage
  2. Peripheral neuritis
  3. Nephrotoxicity
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38
Q

[Alkylating agent]

That has the highest carcinogenic potential

A

Procarbazine

39
Q

Can cause pulmonary fibrosis

A 
Bleomycin
Busulfan
Bromocriptine
Amiodarone
Nitrofurantoin
Methotrexate
40
Q

[Alkylating agent]

Specific to CFU-GM line used as myelosuppressive agent prior to bone marrow transplant

A

Busulfan

41
Q

What enzyme activates 6-mercaptopurine

A

HGPRT

42
Q

What enzyme is inhibited by Fludrabine?

A

Ribonucleotide reductase

43
Q

What enzyme is inhibited by Cladribine

A

Ribonucleotide reductase

44
Q

[Antimetabolite]

used to treat mesothelioma; causes Hand-foot syndrome

A

Pemetrexed

45
Q

[Antimetabolite]

What is the prodrug of 5FU?

A

Tegatur

46
Q

[Antimetabolite]

Used for actinic keratoris and basal call CA?

A

Actinic keratorsis

47
Q

[Antimetabolite]

used in CML in blast crisis

A

cytarabine

48
Q

[Antimetabolite]

Most specific for the S phase of the cell cycle

A

Cytarabine

49
Q

[Antimetabolite]

used for pancreatic CA

A

Gemtacibine

50
Q

___ syndrome

a side effect of some chemotherapeutic drug characterized as redness, swelling, pain, blistering,

A

Hand-foot syndrome

51
Q

[Vinca Alkaloid]

acts primarily in M phase of cell cycle

A

Vincristine

Vinblastine

52
Q

[Vinca Alkaloid]

causes peripheral neuritis

A

Vincristine

53
Q

[Vinca Alkaloid]

Causes bone marrow suppression

A

VinBLASTine

54
Q

Inhibits Topoisomerase II (DNA Gyrase)

A

Etoposide

Teniposide

55
Q

Inhibits topoisomerase I

A

Topotecan

Irinotecan

56
Q

[Campothecin]

used to treat metastatic colorectal CA

A

Irinotecan

57
Q

What is the MOA of Taxanes (paclitaxel)

A

inhibits microtubule DISASSEMBLY

58
Q

What is the MOA of vinca alkaloids?

A

Inhibits microtubule ASSEMBLY

59
Q

What is the MOA of Doxorubicin?

A
  1. Intercalates between base pairs
  2. Inhibits topoisomerase II
  3. generate free radicals
60
Q

Type of cardiomyopathy due to Doxorubicin?

A

Dilated CMP

61
Q

Antitumor antibiotics used in superficial bladder CA

A

Mitomycin

62
Q

What antitumor antibiotic is most specific for the G2 phase of the cell cycle

A

Bleomycin

63
Q

What is the oldest antitumor antibiotic?

A

Actinomycin/Dactinomycin

64
Q

What oncogene that causes that CML acted upon by your tyrosine kinase inhibitors?

A

bcr-abl

65
Q

What oncogene that causes GIST that is acted upon by your tyrosine kinase inhibitors?

A

c-kit

66
Q

What Tyrosine Kinase is used for Idiopathic Pulmonary Fibrosis?

A

Nintedanib

67
Q

MAB used for Her2/neu receptor positive breast CA

A

Trastuzumab

68
Q

An antimetastatic breast CA drug that can cause congestive heart failure

A

trastuzumab

69
Q

MAB that inhibits VEGF/VEGFR signaling

A

Bevacizumab

70
Q

MAB that acts as multiple kinase inhibitor against VEGFR1 to 3 kinases used for thyroid CA

A

Lenvatinib

71
Q

Monoclonal antibody used in low grade NHL; it induces complement-mediated lysis, direct cytotoxicity and induction of apoptosis

A

Rituximab

72
Q

MAB that binds to EGFR and inhibits downstream EGFR signaling; enhances response to chemo and radiotherapy

A

Cetuximab

73
Q

MAB used for colorectal CA

A

Cetuximab

74
Q

An EGFR Tyrosine kinase inhibitor used for non-small cell lung CA and pancreatic cancer

A

Erlotinib

75
Q

Interferon used for hairy cell leukemia, CML and T-cell lymphoma

A

Interferon alpha

76
Q

Substrate-depleting enzyme used to treat acute lymphoblastic leukemia

A

Asparaginase

77
Q

Allows DNA transcription and differentiation of immature leukemic promyelocytes into mature granulocytes

A

ATRA

Used in APML

78
Q

What are the components of retinoic acid syndrome?

A

Dyspnea
Fever
Weight gain
peripheral edema

79
Q

A selective estrogen receptor modulator used for hormone-sensitive breast CA; prevents osteoporosis and decreases risk of atherosclerosis

A

Tamoxifen

80
Q

Androgen antagonist used for prostate C; competitive antagonist at androgen receptro

A

Flutamide

81
Q

Androgen antagonist used for surgical castration

A

Nilutamine

82
Q

What is administered with flutamide to prevent acute flare up of prostate cancer

A

Leuprolide

83
Q

An estrogen synthesis inhibitor that inhibits aromatase

A

Anastrazole, Letrozole

84
Q

Hormonal anticancer drug that is used in precocious puberty

A

Anastrazole

Letrozole

85
Q

Hormonal anticancer drug that is effective against breast cancers that have become resistant to tamoxifen

A

Anastrazole

Letrozole

86
Q

Alkylating agent used for brain tumors such as astrocytoma and glioblastoma multiforme

A

Temozolomide

87
Q

Mitotic inhibitor used for metastatic breast Cancer

A

Eribulin

88
Q

What is the MOA of hydroxyurea?

A

Inhibit ribonucleotide reductase

89
Q

MAB that targets CD30 cells used for hodgkin lymphoma

A

Brentuximab

90
Q

What anticancer drug is used as an immunosuppressant in organ transplantation and advanced kidney CA

A

Everolimus
Sirolimus

These are mTOR inhibitor

91
Q

A humanized anti-CD20 MAB used for chronic CLL and follicular lymphoma

A

Obinutuzumab

92
Q

IgG4 isotype antibody that blocks protective mechanism of CA cells allowing immune system to destroy CA cells

A

Pembrolizumab

93
Q

An EGFR-TK inhibitor used for advances non small cell lung CA

A

Osimertinib

94
Q

First therapeutic proteasome inhibitor used for multiple myeloma and mantle cell lymphoma

A

Bortezomib

Cancer (OSI type) (2 decks)

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