Cancer Cell Biology Flashcards Preview

Cancer > Cancer Cell Biology > Flashcards

Flashcards in Cancer Cell Biology Deck (21)
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1
Q

What’s cancer

A

Term for diseases in which abnormal cells divide without control and invade nearby tissues

2
Q

How does cancer invade nearby cells

A

Spreads by blood and lymphatic system

3
Q

Causes of cancer

A

Environmental/lifestyle factors
Environmental carcinogens
Diet- alcohol

Genetics

Inherited -brca in breast cancer

Somatic - RAS in pancreatic cancer

4
Q

Oncogene is

A

Gene when mutated or overexpressed , contributes development of cancer

5
Q

Tumour suppressors leading to cancer

A

Usually both alleles are required to be disrupted to disrupt function

6
Q

In G1 what decision is taken

A

To enter S phase

7
Q

End of G what decision is taken

A

To enter M phase

8
Q

Apoptosis is included in response to

A

DNA damage

Oncogene activation

9
Q

Apoptosis is regulated by

A

P53

10
Q

P53 is a

A

Tumour suppresses

11
Q

Every cell cycle is risk for?

A

Mutation

12
Q

as cancer cells keep dividing what happens

A

cells become starved of nutrients

13
Q

after cells are starved of nutrients what happens next

A

necrosis starts and cells trigger angiogenesis

14
Q

cancer cells secrete factors that

A

drive angiogenesis

15
Q

things needed to activate invasion and metastasis

A
  1. altered cell adhesion
  2. increased motility and local invasion
  3. intravasation, survival in circulation
  4. increased motility and local invasion at distal site
16
Q

metastasis cascade?

A
divsion
new vessel forming to supply new cells
embolism
transport of embolsim through organs
adherance to wall
extravasation
metastasis
17
Q

seed and soil hypothesis

A

local secretion of particular growth factors or chemokines needed by particular tumours may also be a factor

18
Q

which metastasis spreads the fastest

A

lung

19
Q

which metastasis spreads second fastest

A

breast

20
Q

which metastasis spreads 3rd slowest

A

colorectal

21
Q

which metastasis spreads slowest

A

prostate cancer