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Dental Pharmacology > Cancer > Flashcards

Flashcards in Cancer Deck (8)
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1
Q

damage individual nucleotides (tymidine mismatch/ring cleavage) or cause inter-strand crosslinks (these prevent DNA from denaturing and undergoing replication)–>stopped in S phase

A

alkylating agents

2
Q

causes covalent linkages between DNA strands and blocks replication; active site=chloroethyl group

A

platinum alkylating agents

3
Q

initial drugs fabricated for anticancer; block production of normal nucleotides, thus halting replication; insert themselves into DNA and RNA and prevent activity

A

antimetabolites

4
Q

a uracil analog which can undergo conversion to fluorouridine monophosphate; blocks replication at several sites; blocks formation of deoxythymidine and can be incorporated into RNA and block translation

A

5-fluorouracil

5
Q

inhibition of topoisomerase II; intercalation/inhibition of DNA synthesis; generation of ROS; allows topoisomerase to cut but not reassemble

A

anthracyclines

6
Q

target the mitotic spindles, prevent them from forming, so that they can no longer attach to chromosomes and pull them apart during mitosis

A

vinca alkaloids

7
Q

stabilize the mitotic spindles so they can not depolymerize

A

taxanes

8
Q

targets the BCR-ABL fusion and blocks its activity; effect treatment for chronic myelogenous leukemia

A

imatinib mesylate