Breast Histology Flashcards Preview

Y3 OBS AND GYNAE > Breast Histology > Flashcards

Flashcards in Breast Histology Deck (14)
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1
Q

What makes up the secretory tissue of the breast?

A

15-20 lobes, each consisting of tubuloacinar glands that drain via ducts to the nipple

2
Q

What tissues make up the non-lactating breast?

A

Fibrous and adipose tissue surrounding the secretory lobules

3
Q

Describe the duct system in the breast

A

Terminal ductules lead into intralobular collecting ducts that lead into the lactiferous duct for that lobe
The lactiferous duct leads to the nipple

4
Q

How does the epithelium differ between large ducts and secretory acini?

A

Large ducts: columnar

Secretory acini: cuboidal

5
Q

What type of epithelium lines the nipple?

A

Highly pigmented keratinized stratified squamous epithelium

6
Q

Describe the changes that occur in the breast during the menstrual cycle

A

Epithelial cells increase in height
Lumina of ducts become enlarged
Small secretions appear

7
Q

Describe the changes that occur in the breast if pregnancy occurs

A

Elongation and branching of smaller ducts
Proliferation of epithelial and myoepithelial cells
Plasma cells and lymphocytes infiltrate CT
Glandular tissue development
Secretory alveoli mature

8
Q

What effect do oestrogen and progesterone have on secretory and adipose tissue?

A

Stimulate proliferation of secretory tissue

Fibro-fatty tissue becomes sparse

9
Q

By what mechanism of secretion are lipid droplets of milk secreted?

A

Apocrine secretion: droplet buds off with a little bit of cytoplasm with it

10
Q

By what mechanism of secretion are proteins of milk secreted?

A

Merocrine secretion: vesicle containing packaged protein releases only its contents

11
Q

What is the lactiferous sinus?

A

An expanded duct region near the nipple that the lactiferous duct passes through

12
Q

What pink cells surround the secretory epithelial cells in the lobule?

A

Myoepithelial cells

13
Q

What is the basic functional secretory unit of the breast?

A

Terminal duct lobular unit

14
Q

Describe the changes that occur in the breast if menopause occurs

A

Secretory cells of TDLY degenerate leaving ducts

In CT, reduced fibroblasts, collagen and elastin fibres