Breast and Ovarian cancer syndromes Flashcards Preview

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Flashcards in Breast and Ovarian cancer syndromes Deck (30)
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1

Do these breast changes increase risk? Yes/no/slightly/moderately?

Fibroadenoma

no

2

Do these breast changes increase risk? Yes/no/slightly/moderately?

Florid adenoma

slightly

3

Do these breast changes increase risk? Yes/no/slightly/moderately?

Epithelial hyperplasia

no

4

Do these breast changes increase

Atypical lobular hyperplasia

moderately

5

Do these breast changes increase risk? Yes/no/slightly/moderately?

LCIS

yes

6

Do these breast changes increase risk? Yes/no/slightly/moderately?

DCIS

yes

7

DCIS – invasive or non-invasive?

non-invasive

8

DCIS – can u get radiation? Lumpectomy?

yes, yes

9

DCIS – cancer risk with family hx? Ca risk if left untreated?

Up to 40% if fam hx, 30% if untreated

10

Most common cancer lesion name.

IDC

11

Woman with LCIS vs DCIS – which one is more likely to lead to cancer in the same area as LCIS/DCIS biopsy?

DCIS

12

LCIS – what is new br cancer risk after this finding? Is LCIS considered “Affected” in pedigree?

25-30%; no (?)

13

Gail model – what is cutoff in 5-year risk of br ca to be eligible for chemoprevention?

1.7%

14

Jewish rate of BRCA mutation

1/40

15

Which gene, BRCA1 or BRCA2 is predominantly triple negative?

BRCA1

16

PARP treatment for BRCA-related cancer targets which function of cell?

base excision repair

17

A woman has BRCA2 and does not get PGD. Her child inherits a BRCA2 mutation from her, and a PALB2 mutation from dad – does the child’s risk of cancer differ from the mom’s?

yes, they have Fanconi Anemia, and thus increased risk of Leukemia, other blood-based or solid cancers, and also short stature/developmental abnormalities

18

A jewish woman has a BRCA1 mutation. Her sister comes in. What do youtest the sister for?

All three common Jewish BRCA mutations

19

the 5 Li-Fraumeni tumors

Breast, SBLA (sarcoma, brain, leukemia, childhood adrenocortical [ACC])

20

Oophorectomy lowers ov ca risk by how much?

80-90%

21

Cowden – most common type of thyroid cancer associated?

Follicular, (almost never medullary)

22

L’hermite duclos – what is it, and is it associated with any cancer syndromes?

gangliocytoma, Cowden syndrome

rare, presents in 30-40s, can present as hydrocephalus

23

Which of these is not a minor criterion for Cowden?
a. Goiter
b. GI ganglioneuroma
c. Vascular anomalies in brain
d. Colon cancer

trick question, sucker! All are minor criteria (as of 1/8/16)

24

Cowden: is a major criterion a biopsy-driven Lipoma or Trichlemomma?

Trichilemomma.

25

PALB2 is associated with increased risk of which two cancers?

breast, pancreatic

26

Attenuated FAP – is it associated with CHRPE? With upper GI cancers? Which? Any genotypephenotype relationships?

no CHRPE

yes upper GI (thus need upper endoscopy)

5' and 3' mutations lead to more attenuated FAP vs regular FAP

27

Four actions of BRCA

DUCT - like, breast duct

DNA repair
Ubiquitination
Cell cycle
Transcription

28

Cowden - cancers?

BUTT (colon ca = minor criterion)
Breast
Uterine
Thyroid

29

FAP gene?

APC

30

FAP cancers

DBOUGHT (debit)

desmoid
brain
osteomas
upper GI
hepatoblastoma
thyroid