Brain Tumor Chemo Flashcards Preview

Neurology > Brain Tumor Chemo > Flashcards

Flashcards in Brain Tumor Chemo Deck (16)
Loading flashcards...
1
Q

Brain metasteses outnumber primary neoplasms by

A

10:1

2
Q

Most common sites for brain mets to come from

A

Lung, Breast, Unknown, Melanoma

3
Q

80% of mets go where

A

hemispheres

4
Q

Management of mets may include more than just anti-tumor treatment

A

Also managed with steroids to control edema and anticonvulsants for seizures

5
Q

tx of brain mets

A

Surgery is the mainstay since the BBB is a major issue for traditional chemo

6
Q

Resistance to chemotherapy by the tumor cell may be assisted by communication with astrocytes that lead to upregulation of tumor genes that promote survival and more specifically lower tumor cell apoptosis. The protein products of these genes protect tumor cells from chemo

A

ok

7
Q

Temozolamide mech

A

Pro-drug, DNA methylating agent

Labeled for astrocytoma and GBM, Off label for malignant melanoma and glioma

8
Q

AE of temozolomide

A

myelosuppresion, leukopenia, thrombocytopenia,

Teratogen- CAT X

9
Q

Temozolomide used for

A

Astrocytoma/ GBM

10
Q

Resistance to Temozolomide

A

Upregulation of 06- MGMT which repairs the damage done by the methylator

11
Q

Nitrosoureas- mustines

A

DNA alkylators, high cross resistance with other alkylators, highly lipophilic so CROSS BBB EASY

12
Q

AEsof the mustines

A

myelosuppresion, N/V, PULM FIBROSIS, endocrine dysfunction, encephalopathy

13
Q

Carmustine

A

parenteral

14
Q

Lomustine

A

oral…malignant glioma

15
Q

Which of the mustines not only alkylates but also carbamoylates

A

Carmustine

16
Q

chemo fog may be from

A

High TNF-Alpha which may damage mitochondria