Bone remodeling, formation, and growth Flashcards Preview

Pathophysiology > Bone remodeling, formation, and growth > Flashcards

Flashcards in Bone remodeling, formation, and growth Deck (17)
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1
Q

What two processes are in balance for bone remodeling

A

reabsoprtion by the osteoclasts and bone formation by the osteoblasts

2
Q

What is bone remodeling and when does it occur

A

it start when skeletal growth has reached adult size and it is the renewable of bone

3
Q

What hormone is crucial to maintaining the balance of bone remodeling

A

estrogen

4
Q

How does estrogen effect bone remodeling

A

it signals the osteoblasts to release OPG

5
Q

What does OPG do

A

binds to RANKL

6
Q

Why does OPG bind to RANKL

A

so that there is less free floating RANKL to bind to RANK

7
Q

What does RANKL bind to if it doesnt bind with OPG

A

RANK

8
Q

What is RANK

A

a recceptor on osteoclasts that bind to RANKL

9
Q

What happens when RANKL binds to RANK

A

it signals the osteoclasts to reaborb bone

10
Q

So what happens if we get less estrogen

A

there is less OPG being produced by osteoblasts so therefore there are more free floating RANKL to bind to RANK on the osteoblast, causing more reasorption than formation of bone

11
Q

What disease can form without a balanced bone remodeling

A

osteoporosis

and possibly rheumatoid arthritis

12
Q

What are the hormone that control the hormonal control of bone formation

A

PTH
calcitonin
Vit D

13
Q

What does PTH cause the release of

A

calcium from the bone

14
Q

How does PTH cause calcium preservation in the kidneys

A

it increases reabsorption of calcium and reduces reabsroptiion of phosphate

15
Q

What does calcitonin do

A

lowers serum calcium levels by inhibiting osteoclasts, reducing reabsorption in the kidney

16
Q

So whats the difference between PTH and Calcitonin

A

PTH increases serum calcium

Calcitonin decreases serum calcium

17
Q

What does Vit D do

A

increases absorption of calcium in the intestines and increases PTH activity

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