BOLOGNA CH107 Malignant Skin Tumours Flashcards Preview

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Flashcards in BOLOGNA CH107 Malignant Skin Tumours Deck (23)
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1
Q

Which gene is mutated in patients with basal cell naevus syndrome

A

PTCH1

2
Q

Features of Gorlin Syndrome

A

Palmar pits, calcification of falx cerebri, bifid ribs,
Odontogenic keratolysis, macrocephaly, medulloblastoma, ovarian fibromas, cardiac fibromas, bridging of sella turcica, sprengel deformity

3
Q

Intermittent, recreational sun exposure is a less important risk factor than cumulative UV radiation in development of BCC

A

F, other way around

4
Q

BCC appears to have the capacity for infinite growth

A

T

5
Q

BCC can spontaneously regress

A

F = this is not a feature of BCC

6
Q

BCC devoid of stroma failed to proliferate and differentiated into keratin filled cysts in an experiment

A

T

7
Q

Cumulative UV radiation received over time is a significant risk factor is a significant risk factor for SCC

A

T

8
Q

There is a strong correlation between tumour thickness and metastases of SCC

A

T

9
Q

Alterations in TP53 gene are the most common genetic abnormalities found in actinic keratoses, SCC in situ , invasive SCC

A

T

10
Q

keratoacanthomas of Muir Torre Syndrome are more genetically stable than sporadic KA’s

A

False, other way around

11
Q

Ferguson Smith Syndrome is autosomal recessive, due to mutations in TGFBR1 gene

A

F, autosomal dominant

12
Q

Increased risk of SCC but not BCC for those exposed to artificial UV sources

A

F, both

13
Q

Naevus sebaceous predisposes to BCC but not SCC

A

Table 108.2

False, both

14
Q

Porokeratosis , particularly linear, predisposes to SCC but not BCC

A

T

15
Q

Specific HPV subtypes act as co-carcinogens in conjunction with UVR in the early development of SCC

A

T

16
Q

List risk factors for skin cancer in transplant recipients

A

Skin photo types I/II
Cumulative sun exposure
Age at transplantation
Degree and length of immunosuppression

17
Q

Transplant recipients are prone to developing numerous lesion and more likely to suffer local/regional recurrences and metastases

A

T

18
Q

Which HPV strains can be seen in tumours from transplant recipients?

A

Those that occur in benign warts (HPV1, 2)
EV (HPV-5 and others)
High risk oncogenic warts (HPV types 16, 18)
Low risk oncogenic genital warts (HPV 6, 11)

19
Q

Patients who receive haematopoietic transplants experience the same increase in skin cancer as solid organ

A

F, due to shorter duration of immunosuppression hypothesised

20
Q

What is verrucous carcinoma

A

Rare, well differentiated variant of SCC occurring in middle aged and older adults

21
Q

Subtypes of verrucous carcinoma

A
  1. Epithelioma Cuniculatum (plantar surface of the foot)
  2. Giant condyloma acuminata of genitalia (Buschke-Lowenstein tumour)
  3. Oral florid papillomatosis (oral mucosa)
22
Q

Distinguishing between large wart or condyloma acuminatum can be difficult

A

T

23
Q

Verrucous carcinoma often metastasises

A

F , do not usually metastasise but often recur after attempted removal