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Flashcards in Blood Transfusion Deck (35)
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1

List the blood components that make up one donation of blood

Red cells
Platelets
White cells
Plasma

2

When is plasma deemed "fresh frozen plasma"?

If frozen within 8 hours of blood collection, containing the coagulation proteins in the same concn that was present in the patient's blood

3

List some blood products that can be acquired from batches of blood via manufacturing

Albumin
Immunoglobulin
Prothrombin complex concentrates

4

Blood products are made from thousands of donors. True/False?

True
Giving one bottle of blood product to a patient exposes them to thousands of donors

5

What must be done to donor blood to separate it into components?

Anticoagulation

6

For standard blood donation, how often may someone donate blood?

Every 12 weeks
Max 5 a year

7

List the basic criteria for a blood donor

Able to spare 465ml of blood
Minimum weight 50kg
Hb 13.5 (male)/12.5 (female)

8

Who should avoid donating blood?

Infective risk
Transmitting disease (malignancy)
Drug addicts
Recent foreign travel to endemic areas

9

Describe the order/position of blood components in a bag once blood has been centrifuged

Red cells at bottom (most dense)
Platelets + white cells in middle
Plasma at top (least dense)

10

At what temperature must red cells be stored?

4'C +/- 2'C

11

What is the shelf life of donated red cells? What happens if they are removed from storage for more than 30 mins?

35 days
If removed for more than 30 mins, must be transfused or discarded

12

At what temperature must platelets be stored?

22'C

13

What is the shelf life of donated platelets?

7 days if bacterial monitoring system applied

14

At what temperature and for how long must fresh frozen plasma be stored?

-30'C for up to 3 years

15

What are the possible blood groups a person can be?

A
B
AB
O

16

Describe the red cell membranes of ABO blood groups

A: carry A-antigen
B: carry B-antigen
AB: carry A-antigen + B-antigen
O: no A or B antigen

17

Order the blood groups from highest to lowest population frequency

O, A, B, AB

18

Which of the ABO blood groups is the universal donor? Why?

O is universal donor because blood carries no antigen and therefore other blood groups won't form antibody against it

19

Which of the ABO blood groups is the universal recipient? Why?

AB is universal recipient because it carries both antigens and therefore won't form antibody against any of the other blood groups

20

Naturally occuring ABO antibodies are what - Ig?

IgM
Small proportion are IgG

21

The genes that determine our ABO group are located on which chromosome?

Chromosome 9

22

Which alleles for ABO group are dominant?

A and B are co-dominant
O is recessive

23

The genes that determine Rhesus-D status are located on which chromosome?

Chromosome 1

24

Inheritance of Rhesus-D follows what pattern?

Autosomal dominant

25

How is blood group determined?

Agglutination
Giving antibody to individual of same blood type (e.g. anti-A to group A) will cause cells to stick together

26

What must a doctor's prescription for blood transfusion state?

Number of units
Special requirements
Rate of transfusion
Accompanying medication

27

List possible indications for red cell transfusion in anaemia

Reduced exercise capacity
Medical/surgical issue
Heart or lung disease
"anaemic" symptoms

28

List physiological response to acute blood loss

Increased heart rate + force of contraction
Vasoconstriction to protect organs
Fluid shift from ECF to ICF

29

List indications for platelet transfusion

Low platelet count (duh!)
Bleeding symptoms
Underlying infection/fever
Surgical requirement/recovery
Platelet functional defects (myeloma)

30

List indications for fresh frozen plasma transfusion

Liver disease (impaired coagulation)
Disseminated intravascular coagluation