Blood Lecture 2 Plasma Antibody Complement Immunity Ch10 Flashcards Preview

CVPR 330 Blood > Blood Lecture 2 Plasma Antibody Complement Immunity Ch10 > Flashcards

Flashcards in Blood Lecture 2 Plasma Antibody Complement Immunity Ch10 Deck (35)
Loading flashcards...
1

Primary function of plasma that Moves in and out of vascular system across the capillary membranes ?

Transportation of:
- cells, electrolytes, vitamins, carbohydrates,
proteins and lipids
– Remove waste

2

Serum is

- Plasma minus Plasminogen
- Serum is the liquid portion of
the blood after a clot has
formed

3

Plasma is

- the liquid portion of the blood
mostly H2O.
- 4% of TBW

4

7 Plasma proteins functions

– Maintain osmotic pressure
and therefore fluid volume.
– Transport molecules
(hormones, vitamins, drugs).
– Coagulation
– Enzymes for numerous
chemical reactions.
– Buffer system to maintain pH.
– Nutritional back up.
– Immunity

5

The majority of plasma proteins are synthesized in the Liver.
Name the 3 classes of plasma proteins.

• Albumin 60%
• Globulins 40%
• Fibrinogen

6

Albumins primary functions?

- Maintains osmotic pressure BETWEEN BLOOD AND body tissue.
- Major transport carrier of
other molecules

7

Albumin deficiency can promote what?

- Edema, due to fluid retention in the interstitial space.

8

Name 3 Globulins ?

– Complement proteins
– Immunoglobulins (Ab)
– Antithrombin III (ATIII)

9

Globulin is a generic term used to describe all proteins in the plasma except what?

- Albumin &
- Fibrinogen

10

Globulins Functions ?

- Act as enzymes in many
metabolic processes.
- Responsible for humoral
immunity
- Transportation of:
- heme, hormones, & metals

11

Four types of globulin proteins

Alpha 1
Alpha 2
Beta 1
Immunoglobulins

12

Fibrinogen

- Inactive form of fibrin
- clotting protein that stabilizes
the platelet plug
- Protein with highest affinity
for extracorporeal surfaces.

13

Hypofibrinogenemia

100 mg/dl

14

Hypoproteinemia

Decreased plasma protein
concentration due to:
– Malnutrition
- malabsorption
- excretion
- hemodilution
- (cirrhosis)

15

Hyperproteinemia

Increased plasma protein
concentration due to:
- Dehydration
- Multiple Myeloma (production
of paraproteins)
- Hyperviscosity = clotting in
microvasculature.

16

treatment for Hyperproteinemia

• therapeutic plasmapherisis
• Suppress synthesis of paraproteins

17

Non-Protein plasma solutes

• Electrolytes
• Carbohydrates
• Lipids

18

What is the primary plasma carbohydrate ?
What is the normal level?

Glucose
72-137 mg/dl

19

Cholesterol normal level ?

< 200 mg/dl

20

Lipoprotein normal level?

< 50 mg.dl

21

Complement System

* is part of the innate
immune reaction
* 25-30 inactive soluble
proteins.
* Vasoactive molecules that take a part in the inflammatory response.

22

Complement function

- Antigen destruction
- Inflammatory response to
tissue injury; Increase
vascular permeability
- Immune protection until
antibody can reach full force
7-14 days.
- Opsonization
- Lysis

23

3 Complement Pathways

• Classical Pathway
• Alternative
• Lectin Pathway

24

All complement pathways lead into a common pathway
which produces what ?


Membrane Attack
Complex (MAC)

25

Classical pathway
Triggered by:

antigen opsonized by either
IgM or IgG

26

Alternate pathway
Triggered by:

– Polysaccharide and lipopolysaccharides found
on the outer membrane of microorganisms
– Toxins produced by microorganisms
– IgA and IgG
– CPB

27

The following indicate that the protein has been cleaved into its active components

“a” and “b”

28

Anaphyoltoxin:

Active components that
don’t end up stuck to a cell may have strong
inflammatory influence.
– C3a, C4a, C5a

29

Membrane attack complex

- Group of 5 Complement
proteins (C5, C6, C7, C8,
C9)
- Create a hole in the cell
membrane leading to
destruction of the cell

30

Foreign surface of the ECC activates what?

Complement system