Blood Lecture 1 / Ch 1 The concept of blood Flashcards Preview

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Flashcards in Blood Lecture 1 / Ch 1 The concept of blood Deck (68)
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1

Wha are the 3 Functions of Blood ?

- Transportation: Delivery of
Oxygen, Hormones,
Nutrients, and Minerals.
Removal of waste products
- Hemostasis
- Primary carrier of immunity

2

The average adults Total Blood Volume?

4-6 L which accounts for 7% of TBW.

3

Blood is composed of ?

– Plasma = 55%
– Formed Elements = 45%

4

Plasma is clear straw colored, viscous, and composed of

• 90% water
• 10% solids

5

Formed Elements found in blood account for 45% of the composition of blood, what are they?

- RBC (Erythrocytes)
- WBC (Leukocytes)
- Platelets (Thrombocytes)

6

Organelles within the cell?

• Nucleus
• Endoplasmic reticulum (ER)
• Mitochondria
• Golgi Complex
• Ribosomes

7

Formed elements of the blood are cells with a very specific function. What are the elements that do NOT contain a nucleus?

• RBC and Platelets

8

Formed elements of the blood are cells with a very specific function. What are the elements that DO contain a nucleus?

• WBC

9

WBC depends upon ___ ___ to performits specialized function

protein synthesis

10

Blood Cell Production in the 3rd WEEK begins in ?

Yolk sac

11

Blood Cell Production in the 3rd MONTH begins in ?

Liver
Spleen
Thymus

12

Blood Cell Production in the 4th MONTH begins in ?

Bone Marrow

13

The production of mature blood cells from primitive cells in the bone marrow called?

Stem Cells

14

Hormonally controlledHematopoietic Growth Factors are also know as ?

cytokines

15

How many cells are produced daily?

1 Trillion

16

During Regulation of Hematopoiesis, Multipotent stem cells are influenced by cytokines and growth factors to differentiate into ?

Unipotential cells which ultimately becomemature blood cells

17

During Regulation of Hematopoiesis, Hormonal influence is exerted by?

– Cytokines (IL-#)
– Growth Factors (Il-#, CSF, EPO, Thrombopoietins)
– Vitamins, metals amino acids

18

Erythrocytes

• Released from bone marrow fully mature
• Cary Oxygen and CO2
• No Nucleus - No Cell division

19

A nucleated RBC would indicate what ?

extramedullary hematopoiesis

20

Erythropoiesis

Production of red blood cells by bone marrow

21

Decreased blood oxygen concentration detected by the kidneys would release what ?

Erythropoietin (EPO) is released from the kidney’s peritubular cells > Stimulates stem cells in the bone marrow to produce red cells

22

RBC Shape

Biconcave Disk– 7μ x 2μ
• Shape provides maximum surface area for maximum gas transfer.
• Flexible
• Traverse capillaries in Rouleaux Formation (single file)

23

RBC Life Span

120 days once the mature cell is releasedinto circulation

24

Reticulocytes

(immature RBC) found incirculation after blood loss

25

RBCs rupture when they die– Pieces are removed by macrophages in

the liver and spleen

26

RBC particles are called

“ghosts” or “cellstroma”

27

RBC quantity

4-6 Million RBC / μL

28

Pathologic states effecting RBC #

– Erythrocytosis– Anemia

29

Erythrocytosis AKA

Polycythemia (Too many RBC)

30

Polycythemia Vera (PV) AKA:

erythema
Hgb > 18g/dL
RBC > 6.2X10^12/L
Hct > 55%