Flashcards in Blood Bank Chapter 6 ABO Blood Group System Deck (16)
ABO antibodies are what type of immunoglobulin?
IgM (can be a little IgG)
ABO genes are on this chromosome
A newborn has this number of antigen sites compared to an adult
25-50% of sites on an adults RBC
ABH antigen formation results from
The interaction of genes at 3 seperate loci (ABO, Hh, and Se)
H antigen-precursor for A and B forms what?
type 2 chain - beta1-4 linkage- galactose is attached to N-acetylglucosamine
What is H gene and its functions?
An enzyme, fucosyltransferase- adds fucose to terminal galactose of type 2 chain.
immunodominant sugar-sugar that determines specificity
Which ABO group has the highest amount of H?
Which ABO group has the least amount of H?
What does B gene produce?
Which ABO blood group is more efficient? A or B?
Group B is more efficient. ( a sites- 600,000 b sites 720,000 )
Sese is a secreter? (T/F)
Sese is a secretor, (80% of US are secretors)
Dolichos biflorus agglutinates what cells?
A1 or A1B
Group I ABO discrepancy
unexpected reactions in the reverse due to weak reacting or missing antibodies
reasons include newborns, elderly, CLL, lymphoma...