Flashcards in Blood Bank Chapter 6 ABO Blood Group System Deck (16)
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1
ABO antibodies are what type of immunoglobulin?
IgM (can be a little IgG)
2
ABO genes are on this chromosome
Chromosome 9
3
A newborn has this number of antigen sites compared to an adult
25-50% of sites on an adults RBC
4
ABH antigen formation results from
The interaction of genes at 3 seperate loci (ABO, Hh, and Se)
5
H antigen-precursor for A and B forms what?
type 2 chain - beta1-4 linkage- galactose is attached to N-acetylglucosamine
6
What is H gene and its functions?
An enzyme, fucosyltransferase- adds fucose to terminal galactose of type 2 chain.
7
Terminal Sugar
immunodominant sugar-sugar that determines specificity
8
Which ABO group has the highest amount of H?
Group O
9
Which ABO group has the least amount of H?
A_1B
10
A gene-produces?
N-acetylgalactosaminyltransferase
11
What does B gene produce?
D- galactosyltransferase-
12
Which ABO blood group is more efficient? A or B?
Group B is more efficient. ( a sites- 600,000 b sites 720,000 )
13
Sese is a secreter? (T/F)
Sese is a secretor, (80% of US are secretors)
14
Dolichos biflorus agglutinates what cells?
A1 or A1B
15
Group I ABO discrepancy
unexpected reactions in the reverse due to weak reacting or missing antibodies
reasons include newborns, elderly, CLL, lymphoma...
16
