Blood Bank Ch 8 Other Blood Groups Flashcards Preview

Med Lab Tech Fall 2016 > Blood Bank Ch 8 Other Blood Groups > Flashcards

Flashcards in Blood Bank Ch 8 Other Blood Groups Deck (46)
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1

Terminology for RBC surface antigens. Provides a snatdardized numeric system for naming authenticated antigens.

ISBT (Internationial Society of Blood Transfusion Blood Group Systems)

2

_____ Blood group antigens are not synthesized by the RBCs. These antigens are adsorbed from plasma onto the RBC membrance

Lewis blood group

3

The Le gene codes for __________-, which adds L-fucose to type 1 chains.

L-fucosyltransferase

4

Which genes are needed for form Le^b substance?

Le and Se gene (Le needed for expression of Le^a)

5

lele genotype is more common among blacks than whites and results in what phenotype?

Le(a-b-)

6

(T/F) Lewis antigens are presented poorly expressed at birth.

True Lewis antigens are presented poorly expressed at birth.

7

Lewis antibodies are what type of immunoglobulin?

IgM and are naturally occurring made by Le(a-b-) individuals

8

(T/F) Lewis antigens are infrequently encountered in pregnant women.

False, Lewis antigens are often encountered in pregnant women.

9

(T/F) Lewis antibodies are significant for transusion medicine.

False, Lewis antibodies are not considered significant for transfusion medicine

10

The P blood group consists of biochemically related antigens including?

P, P1, P^k, and LKE

11

(T/F) P1 antigen is greatly expressed at birth

False, P1 antigen is POORLY expressed at birth

12

A common naturally occuring IgM in the sera. It is usually a weak, cold-reactive saline agglutinin and can be neutralized with a certain substance found in hydatid cyst fluid.

Anti-P1

13

Clinically significant alloantibody found in sera of P^k individuals

Alloanti-P

14

This antibody is benign, weak, naturally occurring, saline-reactive IgM autoagglutinin, usually detectable only at 4 degrees Celcius. 

Anti-I

15

This antibody is typically strong cold agglutinin that demonstrates high-titer reactivity at 4C and reacts over a wide thermal range (up to 30-32C)

Pathogenic anti-I

16

Patients with this infection may develop strong agglutinins with autoanti-I specificity.

M. pneumoniae

17

Rare IgM agglutinin that reacts optimally at 4C; potent examples may be associated with infection mononucleosis 

Anti-i

18

These antibodies are cold reactive saline agglutinins that do not bind complement or react with enzyme-treated cells; both may demonstrate dosage.

Anti-M and anti-N

19

Are IgG antibodies, reactive at 37C, and the AHG phase. May bind complement and are associated with HDFN and HTRs

Anti-S and anti-s

20

This MNS blood group phenotype is found in blacks

S-s-U phenotype

21

(T/F) Anti-U is usually an iGG antibody and is assoc. with HTRs and HDFN

True, Anti-U is usually an iGG antibody and is assoc. with HTRs and HDFN

22

23

ABH antigens found in secretions are glyco____?

Glycoproteins

24

The antigens of the Lewis System are?

Le^a and Le^b

25

(T/F) Antibodies in the Kidd system are complement dependent antibodies.

True, Kidd system are complement dependent antibodies.

26

(T/F) Lutheran antibodies are immune and naturally occuring=.

True, Lutheran antibodies are immune and naturally occuring

27

The mcLeod phenotype is associated with the ____ blood group system

Kell blood group

28

Chronic gramulomatous disease is associated with the  _________ blood group system

Kell

29

Antibodies in the Duffy system are usually detected at?

AHG only

30

Antibodies in the Duffy system usually occur as?

Immune antibodies