Terminology for RBC surface antigens. Provides a snatdardized numeric system for naming authenticated antigens.
ISBT (Internationial Society of Blood Transfusion Blood Group Systems)
_____ Blood group antigens are not synthesized by the RBCs. These antigens are adsorbed from plasma onto the RBC membrance
Lewis blood group
The Le gene codes for __________-, which adds L-fucose to type 1 chains.
L-fucosyltransferase
Which genes are needed for form Le^b substance?
Le and Se gene (Le needed for expression of Le^a)
lele genotype is more common among blacks than whites and results in what phenotype?
Le(a-b-)
(T/F) Lewis antigens are presented poorly expressed at birth.
True Lewis antigens are presented poorly expressed at birth.
Lewis antibodies are what type of immunoglobulin?
IgM and are naturally occurring made by Le(a-b-) individuals
(T/F) Lewis antigens are infrequently encountered in pregnant women.
False, Lewis antigens are often encountered in pregnant women.
(T/F) Lewis antibodies are significant for transusion medicine.
False, Lewis antibodies are not considered significant for transfusion medicine
The P blood group consists of biochemically related antigens including?
P, P1, P^k, and LKE
(T/F) P1 antigen is greatly expressed at birth
False, P1 antigen is POORLY expressed at birth
A common naturally occuring IgM in the sera. It is usually a weak, cold-reactive saline agglutinin and can be neutralized with a certain substance found in hydatid cyst fluid.
Anti-P1
Clinically significant alloantibody found in sera of P^k individuals
Alloanti-P
This antibody is benign, weak, naturally occurring, saline-reactive IgM autoagglutinin, usually detectable only at 4 degrees Celcius.
Anti-I
This antibody is typically strong cold agglutinin that demonstrates high-titer reactivity at 4C and reacts over a wide thermal range (up to 30-32C)
Pathogenic anti-I
Patients with this infection may develop strong agglutinins with autoanti-I specificity.
M. pneumoniae
Rare IgM agglutinin that reacts optimally at 4C; potent examples may be associated with infection mononucleosis
Anti-i
These antibodies are cold reactive saline agglutinins that do not bind complement or react with enzyme-treated cells; both may demonstrate dosage.
Anti-M and anti-N
Are IgG antibodies, reactive at 37C, and the AHG phase. May bind complement and are associated with HDFN and HTRs
Anti-S and anti-s
This MNS blood group phenotype is found in blacks
S-s-U phenotype
(T/F) Anti-U is usually an iGG antibody and is assoc. with HTRs and HDFN
True, Anti-U is usually an iGG antibody and is assoc. with HTRs and HDFN
ABH antigens found in secretions are glyco____?
Glycoproteins
The antigens of the Lewis System are?
Le^a and Le^b
(T/F) Antibodies in the Kidd system are complement dependent antibodies.
True, Kidd system are complement dependent antibodies.
(T/F) Lutheran antibodies are immune and naturally occuring=.
True, Lutheran antibodies are immune and naturally occuring
The mcLeod phenotype is associated with the ____ blood group system
Kell blood group
Chronic gramulomatous disease is associated with the _________ blood group system
Kell
Antibodies in the Duffy system are usually detected at?
AHG only
Antibodies in the Duffy system usually occur as?
Immune antibodies
