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Flashcards in Blood Deck (317)
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121

Erythropoetin

  • Size (in mouse)
  • Producing cell
  • Target Cell

  • Size: 51,000 Da
  • Producing cell: Kidney cells
  • Target cell: CFU

(RBCs)

122

Interleukin-3 (IL-3)

  • Size (in mouse)
  • Producing cell
  • Target Cell

  • Size: 25,000 Da
  • Producing cell: T-lymphocyte, epidermis
  • Target Cell: CFU, progenitor and mature cells

123

Granulocyte/Macrophage SF (GM-SF)

  • Size (in mouse)
  • Producing cell
  • Target Cell

  • Size: 23,000
  • Producing cell: T-lymphocyte, endothel, fibroblast
  • Target cell: GM progenitor cells

124

Granulocyte CSF (G-CSF)

  • Size (in mouse)
  • Producing cell
  • Target Cell

  • Size: 25,000 Da
  • Producing cell: Macrophage, fibroblast
  • Target cell: GM progenitor and neutrophil

125

Macrophage CSF (M-CSF)

  • Size (in mouse)
  • Producing cell
  • Target Cell

  • Size: 70,000 Da
  • Producing cell: Fibroblast, macrophage, endothel
  • Target cell: GM progenitor and Macrophage

126

Steel factor

  • Size (in mouse)
  • Producing cell
  • Target Cell

  • Size: 40-50,000 Da
  • Producing cell: Stroma of many organs
  • Target cell: CFU

(RBCs)

127

White blood cells

  • Develop in bone marrow, except lymphocytes
  • Mammals: 5-15 x 109/Lblood
  • Birds: 20-30 x 109/Lblood
  • Dependent on: Age, sex, time of day

128

The pathological increase in the number of the white blood cells

Leukocytosis

129

Causes of leukocytosis

  • Bacterial infection
  • Viral infection
  • Parasitic infection
  • Inflammatory processes

130

Decrease of white blood cells

Leukopenia

131

Leukopenia can be caused by

  • Radiation
  • Mushroom toxins
  • Medications

132

Neutrophyl, eosinophyl and basophyl are kinds of...

Granulocyte

133

Lymphocyte and monocyte are types of...

Agranulocyte

134

Neutrophil is ...% neutrophylic

60%

135

Lymphocyte is ...% lymphocytic

60%

136

Neutrophylic WBCs are found in...

Horses, carnivores, humans

137

Lymphocytic WBCs are found in...

Ruminants, swine, birds

138

Neutrophil granulocyte

  • 10-14µm
  • Segmented nucleus
  • Lysosomes present
  • Previous meeting of pathogens not necessary for elimination

139

Lifetime of neutrophil granulocytes

Circulation: 6-7 hours

Tissue: 2-3 days

140

Where are Neutrophil granulocytes produced?

What is the mobilisation of these called?

  • Bone marrow
  • Spleen

Mobilised during Leukocytosis

141

What are the % compositions of granules in the Neutrophil granulocyte

  • 80% neutrophil
  • 20% azurophil

142

List the enzymes of granules in a Neutrophil granulocyte

  • Lysosyme
  • Nuclease
  • Protease
  • Myeloperoxidase
  • Superoxid dismutase
  • Acidic/alkalic phosphatase

143

Describe the adhesion of white blood cells

WBCs adhere to the wall of capillaries

144

Describe the final developmental stages of the neutrophil granulocytes

  1. Young cells - Stick-shaped nucleus
  2. Becomes more segmented
  3. Stick shape increases with infection rate
  4. Granulocytopenia in decreased development

145

What are the developmental stages of neutrophil granulocytes

  • Young forms
    • Stick shape
    • Bean form
  • Matured neutrophil (3-5 segmented nucleus)
  • Over matured neutrophil (5-10 segmented nucleus)

146

What is the 'shift to the left' in blood count?

  • Forced hematopoiesis
  • Presence of fresh (acute) infection

147

What is the 'shift to the right' in blood count?

  • Presence of aged neutrophil granulocytes
  • Incomplete hematopoiesis

148

Neutrophil granulocyte migration is based on

Actin bundles:

  • Contractile
  • Gel-forming
  • Tightly united

 

149

Describe Diapedesis of Neutrophil granulocyte

  1. Granulocyte phyllopodium adheres between capillary enothelial cells
  2. Granulocyte moves between the endothelial cells
  3. Cell moves into the interstitial space

150

A complex consisting of three small and three bigger peptides

Clathrin