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Flashcards in Biochemistry Deck (372)
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91

What kind of pregnancy is more common in Kartagener syndrome?

ectopic

92

What is the sterol of fungal cell walls?

ergosterol

93

Vimentin is an immunohistochemical marker of what tissue type?

connective tissue

94

Desmin is an immunohistochemical marker of what tissue type?

muscle

95

Cytokeratin is an immunohistochemical marker of what tissue type?

epithelial

96

GFAP is an immunohistochemical marker of what tissue type?

neuroglia

97

Oubain inhibits what transporter?

Na+/K+ ATPase

98

Where on the Na+/K+ ATPase does Oubain bind?

K+ binding site

99

What are three tissues where Type I collagen is found?

bone, tendon, skin

100

Where is type two cartilage found?

cartilage

101

What type of collagen is found in blood vessels?

type three

102

What type of collagen is targeted in Alport syndrome?

Type 4

103

What type of collagen is targeted in Goodpasture syndrome?

Type 4

104

Collagen is composed of 1/3 of what amino acid?

glycine

105

What do X and Y of Gly-X-Y stand for?

proline and lysine

106

What type of post-translational modification occurs to collagen other than hydroxylation? At what residues?

glycosylation

hydroxylysine

107

Problems forming the triple helix of collagen result in what disease?

Osteogenesis Imperfecta

108

What is cleaved to form tropocollagen from procollagen?

disulfide rich regions

109

What enzyme forms cross-links in tropocollagen? What is required as a co-factor?

lysyl oxidase

copper (2+)

110

What disease results if lysyl oxidase is defective?

Ehlers-Danlos Syndrome

111

The most common form of osteogenesis imperfecta is caused by what defects in what type of collagen?

Type I

112

Where does a berry aneurysm occur? What disease predisposes one to a berry aneurysm?

cerebral artery bifurcating from CoW

Ehlers Danlos

113

What is not absorbed in Menkes Disease? What are two characteristics of the most common manifestation of Menkes Disease?

Copper

brittle and kinky hair

114

Elastin is rich in which two amino acids? Hydroxyated or non-hydroxylated?

proline and glycine

non-hydroxylated

115

What inhibits elastase?

α1 anti-trypsin

116

Marfan syndrome is characterized by a defect in what protein? What is the purpose of this protein?

fibrillin

bundle elastin

117

What cytokine cannot bind fibrillin in Marfan syndrome? What two body parts can result in a fatality in marfan syndrome?

TGF-β

aorta and heart valves

118

What is the mnenomic for remembering what southern, northern and western blots look for?

SNoW DRoP

119

An indirect ELISA uses what as a probe? What is being looked for?

indirect = antigen

looking for antibody

120

A direct ELISA uses what as a probe? What is being looked for?

direct = antibody

looking for antigen