Flashcards in benzo Deck (23)
benzos work on __ receptor
GABA A , chloride , hyperpolarization , inhibitory
what are the five principle effects of benzos
skeletal muscle relaxation
__ reverses benzos
do benzos induce microsomal enzymes?
benzos vs. barbs
less abuse potential
greater margin of safety
fewer drug reactions
less addiction potential
benzos give you retrograde or anterograde amnesia?
anterograde (new information)
NOT retrograde (stored information)
should you change your NMB dose due to benzos?
no, muscle relaxation due to central origin, NOT at neuromuscular junction
benzos are drugs with a __ ring fused to a __ ring
5-aryl substituent and 1,4 diazepine ring
what is the principle INHIBITORY neurotransmitter in the CNS?
benzos enhance opening of __ gated channels resulting in __polarization and rendering them resistant to excitation
do benzos, barbs, and alcohol work on the same physical receptor site?
no, different sites and mechanisms, but cross tolerance possible
most common side effects of benzos?
fatigue and drowsiness
sedation usually disappears in 2 weeks
benzos have no significant BP or HR effects, but __ ventilation effects
do benzos suppress adrenal cortisol levels?
two pathways for metabolism of benzos
-hepatic microsomal enzyme metabolism
glucuronidation is the exclusive pathway for 3 benzos, results in __ active metabolites, __ effect by aging
lorazepam, oxazepam, temazepam
little effect by aging
metabolism via hepatic microsomal enzymes produces __ metabolites and __ to aging and liver disease
sensitive to aging and liver disease
what is pregancy category for benzos
D or X
midazolam is __ soluble and has a __ ring where it gets its name, __ x more potent than diazepam
2-3x more potent
at pH less than 4, the imidazole ring is __ and is __ soluble
parenteral preps of versed buffered to pH __
when midazolam hits physio pH, the imidazole ring __ and becomes __ soluble