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ANPH 500 - Pharmacology - McCarver > benzo > Flashcards

Flashcards in benzo Deck (23)
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benzos work on __ receptor

GABA A , chloride , hyperpolarization , inhibitory

1

what are the five principle effects of benzos

sedation
anxiolysis
anticonvulsant
skeletal muscle relaxation
anterograde amnesia

2

__ reverses benzos

flumazenil

3

do benzos induce microsomal enzymes?

no

4

benzos vs. barbs

less tolerance
less abuse potential
greater margin of safety
fewer drug reactions
less addiction potential

5

benzos give you retrograde or anterograde amnesia?

anterograde (new information)

NOT retrograde (stored information)

6

should you change your NMB dose due to benzos?

no, muscle relaxation due to central origin, NOT at neuromuscular junction

7

benzos are drugs with a __ ring fused to a __ ring

benzene ring
diazepine ring

5-aryl substituent and 1,4 diazepine ring

8

what is the principle INHIBITORY neurotransmitter in the CNS?

GABA

9

benzos enhance opening of __ gated channels resulting in __polarization and rendering them resistant to excitation

chloride gated

hyperpolarization

10

do benzos, barbs, and alcohol work on the same physical receptor site?

no, different sites and mechanisms, but cross tolerance possible

11

most common side effects of benzos?

fatigue and drowsiness

sedation usually disappears in 2 weeks

12

benzos have no significant BP or HR effects, but __ ventilation effects

minimal

13

do benzos suppress adrenal cortisol levels?

yes

14

two pathways for metabolism of benzos

-glucuronidation
-hepatic microsomal enzyme metabolism

15

glucuronidation is the exclusive pathway for 3 benzos, results in __ active metabolites, __ effect by aging

lorazepam, oxazepam, temazepam

no metabolites

little effect by aging

16

metabolism via hepatic microsomal enzymes produces __ metabolites and __ to aging and liver disease

active metabolites

sensitive to aging and liver disease

17

what is pregancy category for benzos

D or X

18

midazolam is __ soluble and has a __ ring where it gets its name, __ x more potent than diazepam

water soluble

imidazole ring

2-3x more potent

19

at pH less than 4, the imidazole ring is __ and is __ soluble

open ring

water soluble

20

midazolam pKa

parenteral preps of versed buffered to pH __

6.1

3.5

21

when midazolam hits physio pH, the imidazole ring __ and becomes __ soluble

ring closes

lipid soluble

22

midazolam is prepped in water soluble preparation unlike diazepam which comes in __

propylene glycol