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Flashcards in BCGP Hyperlipidemia Deck (25)
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1
Q

which of the statins is not associated to reduce LDL and total cholesterol in pt with familial hypercholesterolemia

A

lovastatin

2
Q

which immunosupressive agent improve lipid panel

A

cyclosporin

3
Q

Formula LCL-C

A

LDL-C = (TC) – (triglycerides/5) – (HDL-C).

4
Q

LDL lowering drugs

A

statins
ezetimibe,
bile acid sequestrants, and
PCSK9 inhibitors

5
Q

TG lowering drugs

A

niacin and fibrates (have mild ldl lowering action)

6
Q

High intensity statins

A

lowers by 50%
rosuvastatin 20mg and 40mg
atorvastatin 40 and 80mg

7
Q

moderate intensity statins

A

30-49%

Atorvastatin 10 mg (20 mg)
Rosuvastatin (5 mg) 10 mg
Simvastatin 20–40 mg§

Pravastatin 40 mg (80 mg)
Lovastatin 40 mg (80 mg)
Fluvastatin XL 80 mg
Fluvastatin 40 mg BID
Pitavastatin 1–4 mg
8
Q

low intensity statins

A

<30%

simvastatin 10mg
Pravastatin 10–20 mg
Lovastatin 20 mg
Fluvastatin 20–40 mg

9
Q

ezetimibe

A

lowers LDL-C levels by 13% to 20%

10
Q

bile acid

A

reduce LDL-C levels by 15% to 30%
not abs system
causes constipation
can cause severe hypertriglyceridemia

11
Q

75 years of age or younger with not high risk ASCVD

A

high-intensity statin therapy should be initiated or continued with the aim of achieving a 50% or greater reduction in LDL-C levels

12
Q

75 years of age or younger with non high risk clinical ASCVD on max statins and LDL >70

A

add ezetimibe

13
Q

75+ yo and non high risk ASCVD

A

moderate intensity statins

14
Q

high risk ASCVD

A

initiate high intensity, high dose statins

if LDL-C still above 70, add ezetimibe OR if consider PCSK9 - add ezetimibe first, then PCSK9

15
Q

40-75yo with DM

A

moderate intensity statins

16
Q

LDL-C >190

A

high intensity statins

17
Q

0-19yo with familial HLD

A

statins

18
Q

20-39yo, familial HLD and LDL-C >160

A

consider statin

19
Q

40-75 yo
LDL-C 70-190 without dm
has ASCVD < 5 (low risk)

A

life style change

20
Q

40-75 yo
LDL-C 70-190 without dm
has ASCVD 5-7.5 (border line)

A

risk discussion

consider moderate statins

21
Q

40-75 yo
LDL-C 70-190 without dm
has ASCVD 7.5-20 (intermediate risk)

A

risk discussion

consider statins with 30-49 % reduction

22
Q

40-75 yo
LDL-C 70-190 without dm
has ASCVD > 20 (high risk)

A

risk discussion and statins >50%

23
Q

20+ yo TG 175- 500

A

life style change

24
Q

40-75 yo with ASCVD > 7.5 TG < 500

A

life style, consider statin

25
Q

40-75 yo with ASCVD > 7.5 TG > 500

A

Life style change and Fibrates