Flashcards in BB Ch 4 121-134 Deck (53)
Give the Order and Family of the laboratory rat.
Which rat strain is a model for mononuclear cell leukemia?
Which rat strain is a model for juvenile insulin-dependent diabetes mellitus?
Name the rat strain that is a model for multiple sclerosis and various experimentally induced autoimmune diseases.
Which rat strain is an obesity model?
The rat strain that is a host for transplantable Morris hepatoma and serves as a model of spontaneous autoimmune thyroiditis.
Which rat strain is a model for spontaneous hypertension?
SHR (Spontaneous Hypertensive Rat)
Which rat strain is a model of myeloma and production of IgG autoantibody?
Which rat strain serves as a model for congenital genitourinary anomalies and prostatic adenocarcinomas?
Which rat strain serves as a model for inducible, transplantable myeloid leukemia, hydronephrosis, and bladder carcinoma?
BN (Brown Norway)
Which rat strain's primary use is as a prostatic adenocarcinoma model?
Which rat strain serves as the inbred rat model for National Toxicology Program's Carcinogen Bioassay Program and the National Institute on Aging?
F-344 (Fischer 344)
Describe important characteristics of the Brattleboro rat strain.
Diabetes insipidus (autosomal recessive)
Describe important characteristics of the Gunn rat strain.
Jaudice, kernicterus (autosomal recessive). Kernicterus is a rare neurological condition that occurs in some newborns with severe jaundice.
Describe important characteristics of the Nude rat strain.
T cell deficient (autosomal recessive)
Describe important characteristics of the Obese SHR.
Type 4 hyperlipoproteinemia (autosomal recessive)
What is the appropriate temperature and humidity for a rat housing area?
20-26C or 68-79F, 30-70% humidity (Guide 8th ed.)
How often should solid bottom rat cages be sanitized?
Name the gland that is associated with chromatodacryorrhea in the rat.
Which pair of salivary glands of the rat is composed entirely of mucous secreting cells?
T or F. Rats have a dividing ridge in their stomach that is an anatomical barrier to vomiting.
True - the ridge is called the limiting ridge or margo plicatus
What is the lobe pattern of the rat lung?
A) 1 right, 4 left
B) 4 right, 1 left
C) 2 right, 4 left
D) 4 left, 2 right
B - 4 right, 1 left (just like the mouse)
T or F. The pulmonary vein of the rat has cardiac striated muscle within its wall and bronchoconstriction is controlled by vagal tone.
Which of the following is not a characteristic of the rat.
A) Cowper’s glands
B) A bicornuate uterus with 2 cervices
C) A unipapillate kidney
D) A foramen of Magendie
D - rats have no Foramen of Magendie, which drains CSF from the 4th ventricle to the cisterna magna
What type of diet is used most commonly for toxicological and Good Laboratory Practices studies?
A) Certified natural ingredient diet
B) Purified diet
C) Chemically defined diet
D) Closed formula diet
A - GLP studies require that natural ingredient diets be certified to be free of contaminants that can influence study results
At what age does puberty occur in rats?
What is the gestation length of rats?
At what age do the eyes of rat pups open?
14-17d, but the retina is not fully developed until 30-40d
At what age are rat pups typically weaned?
Usually 20-21d, but can be as early as 17d