Basic CNS Biochemistry Flashcards Preview

Medicine, Year 1 Block 6 (Psychological Medicine) > Basic CNS Biochemistry > Flashcards

Flashcards in Basic CNS Biochemistry Deck (16)
Loading flashcards...
1

Neurotransmitters can be divided into broad groups, what are they?

Small molecule neurotransmitters (tend to be fast acting)
Neuropeptides (tend to be slow acting)

2

Small molecule neurotransmitters tend to be packaged in what kind of vesicles?

Small clear vesicles

3

Neuropeptides tend to be packaged in what kind of vesicles?

Large dense core vesicles

4

What is "co-transmission"?

Neurotrons releasing more than one neurotransmitter

5

Botulinum toxin inhibits which protein to prevent pre-synaptic NT release?

SNAREs

6

What are the two broad classes of NT receptor?

Ionotropic
Metabotropic

7

Which enzyme synthesises Acetylcholine? What are the substrates?

Choline acetyltransferase

(Choline + Acetyl-CoA)

8

What are the subtypes for the Muscarinic Acetylcholine Receptor?

M1 M2 M3 M4 M5

9

What are the three Glutamate receptors?

AMPA
NMDA
Kainate

10

What is the mechanism of action for Donepezil?

AchE antagonist

11

What is the precursor for GABA?

Glutamate

12

How is Dopamine synthesised?

Tyrosine --- L-DOPA ----- Dopamine

13

The clinical features of Parkinsons is TRAP. What is TRAP?

Tremor
Rigidity
Akinesia
Postural problems

14

What is the precursor for Noradrenaline?

Dopamine

15

How is 5-HT degraded?

Monoamine Oxidase

16

How is Noradrenaline broken down?

Monoamine Oxidase