Barbiturates Flashcards Preview

ANPH 500 - Pharmacology - McCarver > Barbiturates > Flashcards

Flashcards in Barbiturates Deck (50)
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0

Why have barbs fallen out of favor?

Hangover effect- residual drowsiness lasting many hours

1

Any drug derived from __ acid = a barb

Barbituric acid

2

Barbs are __ salts and are __ soluble in IV fluids

Sodium salts

Highly soluble

3

Because they are highly alkaline, they easily __ with opioids, catecholamines, and NMB

Precipitate

4

Barbs are only available as a __ % solution due to caustic to vessels

2.5%

5

Substitutions at 2 and 5 carbons gives different effects.

Sulfur at 2 and 5-

Sulfur at 2 and 5- increase lipid solubility

6

Substitutions at 2 and 5 carbons gives different effects.

Phenyl at 2 and 5-

Anti-convulsant

7

Substitutions at 2 and 5 carbons gives different effects.

Methyl group at 2 and 5-

Convulsive activity

8

Prompt awakening from barbs is due to

Redistribution

Test question

9

What ion is associated with GABA receptors?

Chloride
Test question

10

Barbs have a unique ability to depress BOTH __ and __

Reticular activating system

SNS ganglia- leading to hypotension

11

Non ionized fraction exerts pharm effect

Test question

12

Patients on highly protein bound meds such as __ and __ increase barb effects

ASA

phenytoin

13

Patients with cirrhosis and neonates have __ sensitivity to barbs

Greater

14

Maximum brain uptake in __ seconds for thiopental and methohexital

30

15

Initial decreases in plasma concentrations of barbs are due to redistribution to __

Skeletal muscle

16

Barb levels continue to rise in __ 30 minutes post injection

Fat

17

Calculate induction drugs using __ body weight

Lean

18

Acidosis __ barb effects

Increases

19

Alkalosis __ barb effects

Decreases

Due to alterations in the non-ionized fractions

20

Cardiopulmonary bypass __ systemic clearance of barbs

Decreases

21

Oxi-barbiturates are metabolized __

Hepatic only

22

Thio-barbs (with the sulfur) metabolize

Mainly hepatic but also kidneys and CNS

23

Barb metabolism is __.

Slow

24

Enzyme induction may __ the dose requirements but does not modify the duration of action.

Increase

25

Do roach of the liver patients have any difference in barb clearance?

No

26

Methohexital hepatic clearance is __x greater than thiopental, therefore it has the least hangover

4x

27

While redistribution determines awakening, __ determines complete recovery.

Metabolism

28

Old age __ anesthetic effects of barbs

Increases

29

Peds patients recover __ due to more rapid hepatic clearance

Quicker