Bacterial CNS and STDs Flashcards
what bacterial CNS infections would you see in a neonate
- Streptococci Groups A, B,
- E. coli K1 capsule (Group B meningitis)
What bacterial CNS infections would you see in children
H. influenza, N.memingitidis
What bacterial CNS infections would you see in adults
N. meningitidis, S. pneumoniae
What is the model for CNS infections
N. Meningitiids
N meningitidis virulence factors
- Capsule (ABCWY),
- Pili (antigenically variable
N meningitidis pathology
lipooligosaccharide, toxic to the vasculature
N meningitidis human only pathogen
non symptomatic carriers
N meningitidis transmission
aerosolized droplets
N meningitidis prevention
- variety of capsular polysaccharide vaccines
- recombinant proteins (group B)
- Polysaccharide conjugates
- Antibiotics
N meningitidis at risk poopulations
- individuals without a spleen
- complement deficiency
- travel to endemic areas
- college freshman
- military recruits
N meningitidis identification
gram negative, diplococci, fastidious oxidase positive
Common properties to N. gonorrhoeae and C. trachomatis
- gram negative
- result in inflammatory symptoms
- target non ciliated columnar epithelial cells in general
- can be asymptomatic in some patients-important for spreading the disease
- should be treated promptly to prevent spread bc reinfections are common
- no vaccine for either organism
- Number 1 (chlamydia) and 2 (N. gonorrhoeae) bacterial STD in the US
Unique properties of Gonococci
- transcytose to deeper tissue layers
- variable expression of antigens and pili to escape immune system
- inflammatory response due to release of cell wall components
Unique properties to Chlamydia
- obligate intracellular parasites
- express a unique developmental cycle for bacteria (EB to RB to EB)
- no peptidoglycan but possess cysteine rich outer membrane proteins
