Bact PNA II (lec 13) Flashcards Preview

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Flashcards in Bact PNA II (lec 13) Deck (19)
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1
Q

Haemophilus influenzae microbe characteristics?

A

G- coccobacillus
Lipooligosacc (LOS) cell wall
Cap and non-cap
Need RBC factors for growth

2
Q

H. flu Virulence Factor?

A

Only Non-typeable strains cause dz

Polyrib phosphate CAPSULE:
Φ phago
Fimbriae attachement
Φ IgA

3
Q

H. flu epidemiology?

A
Opportunistic
Type b (Hib) -> PNA babies
4
Q

H. flu action?

A

bind ciliated epith cells ->
Secrete LOS ->
↓ cilia, inflamm

5
Q

H. flu diagnostic tests?

A

Latex Agg = best test

Gram stain
Serology = capsulated
Cx (chocolate agar) = satellites around other bacteria
Catalase = +

6
Q

H. flu tx?

A

amox

vaccine

7
Q

Legionella pneumophila microbe characteristics?

A
G- bacillus: thin/pleomorphic
Fimbriae
β-lac prdxn
Polar flagellum
Catalase/Oxidase +
8
Q

L. pneumo action?

A

Opsonized w/ C3b ->
phagocytosed ->
multiply in phago ->
phago lysed / toxin released

9
Q

L. pneumo epidemiology?

A

(U) immuno/pulmonary compromised

Moist environ (in H2O)
Replicate in protozoa
Aerosole transmission (NO p-to-p)
(U) serogroup 1

10
Q

L. pneumo causes what 2 dzs?

A

1) Pontiac Fever

2) Legionnaire’s Dz

11
Q

Pontiac Fever presentation?

A

flu-like sxs
No PNA signs
self-limit (2-5 days)

12
Q

Legionnaire’s Disease presentation?

A

Severe, acute Atypical PNA
PNA sxs w/ GI and neuro
High mortality (shock/resp fail)

13
Q

L. pneumo diagnostic tests?

A

Cx on Buffered Char Yeast

Rapid urine antigen

14
Q

L. pneumo DOC?

A

levofloxacin

15
Q

Pseudomonas aeruginosa microbe characteristics?

A

G- motile bacillus
Aerobic
Single flagellum
Blue/green color

*used in bioremediation

16
Q

P. aeruginosa Virulence Factor?

A

Pyocyanin:
ROS pdxn

Exotoxin A:
ciliastasis
immunosupp

Elastases A/B:
Lyse elastin

Alginate Glycocalyx:
Adhesion
Φ phago
Φ mucociliary escalator

Lipopolysacc Endotoxin

17
Q

P. aerug epidemiology?

A

Opportunistic
Widespread: plants, water, soil
Skin/feces, food spread
Many kinds of infections

18
Q

P. aerug diagnostic tests?

A

Tinged sputum
Isolation: water-soluble blue/green, fruity smell

Must run sensitivity (highly resistant)

19
Q

P. aeurg nosocomal PNA DOC?

A

Cefepime + levoflo

Avoid broad-spectrum (suppresses normal flora)