Asthma & COPD Drugs Flashcards Preview

clin mgt Exam 2 > Asthma & COPD Drugs > Flashcards

Flashcards in Asthma & COPD Drugs Deck (25)
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1
Q

what drug is a PDE4 inhibitor

A

Roflumilast

2
Q

SABA drugs

MOI?

A

Albuterol

levalbuterol

Increase CAMP in bronchial SMC ® bronchodilation

3
Q

SAMA

A

Ipratropium (Atrovent)

Bloch Ach receptors on M3 receptors in bronchial tissue ® bronchodilation

4
Q

LABA

A

Salmeterol

Formoterol

(-erol)

5
Q

LAMA

A

Aclidinium

Glycopyrrolate

Tiotropium

Umeclidinium

6
Q

SABA + SAMA

A

Combivent (albuterol-ipratropium)

Duoneb (albuterol-ipratropium)

7
Q

ICS + LAMA + LABA

A

Trelegy

(fluticasone + Umeclidinium + vilanterol)

Breztri

(budesonide + glycopyrrolate + formoterol)

8
Q

LTRA

A
  • Montelukast (Singulair)
  • Zafirlukast (Accolate)

Add on therapy w/ ICS

Alternative therapy for step 2 (not preferred)

9
Q

ICS

A

Beclomethasone

Budesonide - safest in pregnancy

Fluticasone propionate

Fluticasone furoate

Mometasone

Flunisolide

Ciclesonide

10
Q

LAMA in asthma

A

Tiotropium (Spiriva Respimat)

On medium dosed ICS + LABA not well controlled

Add Spiriva before move to biologics

Asthma 6+ years

11
Q

Mast cell Stabilizer

A

Cromolyn sodium (Intal)

Preventative tx prior to exercise of known allergies

Safe in pregnancy

12
Q

biologic MABs

A
  • Xolair (older)
  • Dupixent (newer)

Xolair - Bind to IgE to prevent binding and inhibit signaling

Dup - IL4 receptor alpha antagonist

SEVERE asthma

13
Q

ICS + LABA

A

airDuo (Respiclick)

(Fluticasone propionate + Salmeterol)

Breo Ellipta

(Fluticasone furoate + vilanterol)

14
Q

COPD ridk group initial therapy

A
15
Q

•FEV1/FVC Ratio = < _____%suggests “obstructive” (COPD)

A

<70%

16
Q

CLASSIFY AIRFLOW LIMITATION IN COPD

A
17
Q

markers of hyperinflation

A

INC in FRC

DEC IC

18
Q

define spirometry results for asthma

A
  • FEV1 of > 200 mL and
  • ≥12% increase from baseline measure after SABA
19
Q

how to use DPI vs MDI

A

DPI - inhale deeply and forcefully (no propellant)

MDI - inhale slowly (propellant HFA)

20
Q

sx of asthma vs COPS

A

asthma - Wheezing, breathlessness, chest tightness, coughing

COPD - Chronic sputum production, dyspnea, chronic cough

21
Q

4 ways risk groups are assessed

A

mMRC

CAT

Excerbations

Hospitalizations

22
Q

when to use ICS in COPD

A

EOS >300

hx or concurrent asthma

ICS + LABA
or

ICS + LABA + LAMA

23
Q

what drugs are reccommended for each COPD risk group

A
24
Q

mMRC > 2 IF?

A

hard time keeping up w/ someone their own age on level walking field

25
Q

COPD risk groups bases on symtpm burden and exacerbation risk

A