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Flashcards in Arthropathies Deck (96)
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1

_____ have increased frequency of Heberden’s and Bouchard’s nodes

Women

2

_____ hypothesis: HLA-B27 has a propensity to misfold in the ER, leading to a stress response

Unfolded Protein Hypothesis

3

______ crystals are rhomboid-shaped and ______ bifringent

Calcium pyrophosphate dehyrate (CPPD); positively

4

______ have more severe osteoarthritis.

Women

5

______ hypothesis: homodimers of HLA-B27 heavy chains can trigger activation of Natural Killer (NK) cells through killer cell immunoglobulin-like receptors (KIRs)

Free Heavy Chain

6

______ hypothesis: induction of autoreactivity to self antigens between epitopes of infecting organism/antigen and a portion of the HLA-B27 molecule (or other self peptides)

Molecular Mimicry

7

______ hypothesis: make RF and anti-CCP antibodies that may lead to production of immune complexes, enhancing local inflammation

B cell

8

_______ crystals are enedle shaped and ________ bifringent

monosodium urate; negatively

9

_______ emigrate from circulation under influence of cytokines, IL-8, and TGFb into the synovium

Neutrophils

10

_______ hypothesis: may recognize citrullinated peptides, or proteoglycan or collagen altered by enzymatic degradation with presentation of neoepitopes

T cell

11

_______ hypothesis: microbial peptides that bind to HLA-B27 and then are presented uniquely to CTLs to result in disease

Arthritogenic peptides

12

_______: arthritis, urethritis, inflammatory eye disease, and mucocutaneous lesions

Reiter's Syndrome

13

______: decrease uric acid production in over-producers

Xanthine oxidase inhibitors

14

______: directly opposed to articular cartilage and marginal bone, responsible for most of the joint tissue destruction

Pannus

15

______: enhances renal excretion of uric acid in under-excreters

Uricosuric

16

_____: aggregated deposits of monosodium urate crystals occurring in joints, bones, and soft tissue

Tophi

17

_____: diminished migration, metabolic, and phagocytic activity of PMNs, may block NLRP3 inflammasome activation in monocytes

colchine

18

____: renal interstitial, glomerular, and/or tubular deposition of MSU crystals

Gouty nephropathy

19

Ankylosing Spondylitis Specific Therapy Strategies

Back exercises/Good posture; smoking avoidance (to prevent loss of chest wall function)

20

Bouchard's nodes are bone swellings of the ____ joints

PIP

21

Cause of urethritis in reactive arthritis

Chlamydia

22

Causes of diarrhea in reactive arthritis (4)

Campylobacter, shigella, salmonella, yersinia

23

Factors affecting Monosodium Urate solubility (5)

Temperature, Dehydration; Trauma, Proteolytic abnormalities, pH

24

Gout can result from decreased excretion of uric acid due to activation of _____.

URAT1

25

Gout can result from increased production of uric acid, due to _____ activity of ______ or deficiency of ______.

increased, phosphoribosyl-pyrophosphate synthetase (PRPP); hypoxanthine-guianine phosphoribosyltransferase (HGPRT)

26

Heberden's nodes are bone swellings of the ____ joints

DIP

27

Igs (typically Ig__) that recognize epitopes in _______.

M; the Fc region of IgG

28

In ankylosing spondylitis, ______ may contribute to development of calcification at entheses and in joint

TGF-beta, WNT proteins, Bone Morphogenic Proteins (BMPs)

29

In ankylosing spondylitis, the environmental trigger is unknown but thought to be common to all patients, such as________

normal bowel flora

30

In osteoarthritis, water content _____, proteoglycan content ______, and chondrocyte numer ______.

increases; increases; initially increases then decreases