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Flashcards in Anxiolytic Deck (22)
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1
Q

What are the 4 essentials of diagnosis for anxiety?

A

Overt anxiety or an overt manifestation of a coping mechanism (such as a phobia) or both

Not limited to an adjustment disorder

Somatic symptoms referable to the autonomic nervous system or to a specific organ system (eg, dyspnea, palpitations, paresthesias)

Not a result of physical disorders, psychiatric conditions (eg, schizophrenia), or drug abuse (eg, cocaine)

2
Q

What are common CV medical illnesses associated with anxiety sx?

A

angina

arrhythmias

cardiomyopathy

congestive heart failure

hypertension

ischemic heart disease

mitral valve prolapse

myocardial infarction

3
Q

What are common endocrine & metabolic illnesses associated with anxiety sx?

A

Cushing disease

diabetes

hyperparathyroidism

hyperthyroidism

hypothyroidism

hypoglycemia

hyponatremia

hyperkalemia

pheochromocytoma

vitamin B12 or folate deficiencies

4
Q

What are common GI illnesses associated with anxiety sx?

A

Crohn disease

irritable bowel syndrome

ulcerative colitis

peptic ulcer disease

5
Q

What are common Neurological medical illnesses associated with anxiety sx?

A

Migraine

seizures

stroke

neoplasms

poor pain control

6
Q

What are common Respiratory system illnesses associated with anxiety sx?

A

Asthma, chronic obstructive pulmonary disease, pulmonary embolism, pneumonia

7
Q

What are the 5 1st line drugs for GAD

A

Duloxetine

Escitalopram

Paroxetine

Sertraline

Venlafaxine XR

8
Q

What are the 4 2nd line drugs for GAD?

A

Benzodiazepines

Buspirone

Imipramine

Pregabalin

9
Q

Alternative drugs for GAD

A

Hydroxyzine

Quetiapine

10
Q

1st line drugs for panic disorder?

A

SSRIs

Venlafaxine XR

11
Q

2nd line for panic disorder?

A

Alprazolam

Citalopram

Clomipramine

Clonazepam

Imipramine

12
Q

Alternative drugs for panic disorder?

A

Phenelzine

13
Q

6 1st line drugs for social anxiety d/o?

A

Social anxiety disorder

Escitalopram

Fluvoxamine CR

Paroxetine

Sertraline

Venlafaxine XR

14
Q

2nd line drugs for social anxiety disorder?

A

Clonazepam

Citalopram

15
Q

Alternative drugs for social anxiety disorder?

A

Gabapentin

Phenelzine

Pregabalin

16
Q

partial agonist at 5-HT receptors and possibly D2 receptors

interacts with the 5-HT1A subclass of brain serotonin receptors as a partial agonist

minimal CNS depressant effects (it does not affect driving skills)

no anticonvulsant or muscle relaxant properties

MOA of which drugs?

A

selective anxiolytic

17
Q

What are the PK of anxiolytics?

A

slow onset of action (>1 week)

oral activity

forms active metabolite

interactions with CYP3A4 inducers and inhibitors

short half-life

18
Q

Indications for using Buspirone?

A

used in GAD

less effective in panic disorders

19
Q

Adverse effects of Buspirone

A

GI distress, tachycardia

paresthesia

20
Q

Dependency of Buspirone

A

tolerance development is minimal with chronic use

little rebound anxiety or withdrawal symptoms on discontinuance

21
Q

Is Buspirone safe in pregnancy?

A

Yes

22
Q
A