Anxiety - Dr. C

Question 1

In the DSM-5, there are only 3 anxiety disorders listed, which are ___.

Answer 1

Generalized Anxiety Disorder (GAD)
Panic Disorder
Specific Phobia (simple or social)

Question 2

Of the anxiety disorders, which one is there no good pharmacological therapy for?

Answer 2

Specific phobia

Question 3

True or False: OCD and PTSD are considered anxiety disorders in DSM-4 and DSM-5.

Answer 3

False! They’re not considered anxiety disorders in DSM-5

Question 4

Which GABA receptor subtype is linked to benzodiazepine sites?

Answer 4

GABAa

Question 5

There 2 were the first benzodiazepine agents discovered and used in the 1960s, which were long acting so less withdrawal effects. They did, however, produce a hangover effect.

Answer 5

Chlordiazepoxide

Diazepam

Question 6

Most benzodiazepines are effective in generalized anxiety disorder, but not panic disorder. The only 2 benzos that can be used in panic disorder are __ and ___.

Answer 6

Alprazolam and clonazepam

Question 7

_______ is a competitive antagonist at the benzodiazepine site on GABA receptor that can be used to reverse benzo agonist effects or block inverse agonists. It has a short half-life and most often used in the emergency department.

Answer 7

Flumazenil (aka Ro15-1788)

Question 8

____ are drugs that bind to the receptor and turn the system backwards. So if activating a benzo receptor facilitates the effects of GABA to open the chloride channel, if you give this at a benzo receptor, it will reduce GABA mediated opening of chloride channels! So that might produce convulsions! These still don’t have clinical application.

Answer 8

Inverse agonists

Question 9

True or False: Inverse agonists can produce seizures as well as anxiety.

Answer 9

True

Question 10

Another name for flunitrazepam is _______.

Answer 10

Rohypnol

Question 11

_____ is a strong benzodiazepine site agonist that is used as a date rape drug.

Answer 11

Rohypnol (aka flunitrazepam)