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Flashcards in Antiviral Drugs Deck (26)
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1
Q

What are some reasons for the low amount of few approved anti-vitals?

A
  • Requirement for high specificity
  • Requirement for low toxicity
  • Limited market for highly-specific antivirals
2
Q

Docosanol MOA

A

Long‐chain alcohol that may disturb cell membranes and reduce herpes virus entry into cells

3
Q

Acyclovir MOA

A

Chain‐terminator with HSV DNA polymerase specificity

4
Q

Ganciclovir MOA

A

Chain‐terminator; MOA similar to acyclovir; phosphorylated by viral UL97 kinase

5
Q

What is the preferred ROA of ganciclovir?

A

IV

6
Q

Acyclovir Indications

A

HSV and Herpes Zoster

7
Q

Ganciclovir Indications

A

CMV, HHV6 and 8, and EBV

8
Q

What is the most serious SE of ganciclovir?

A

Bone marrow suppression

9
Q

Foscarnet MOA

A

Inhibits pyrophosphate binding on viral DNA polymerases

10
Q

Foscarnet SE

A
  • High nephrotoxicity
  • Myelosuppression
  • Anemia
11
Q

Where can foscarnet deposit?

A

Bones

12
Q

Pritelivir MOA

A

Helicase – primase inhibitor that blocks viral DNA replication

13
Q

Ribavirin MOA

A

Deplete GTP pools, directly block viral RNA polymerase, introduce catastrophic errors during viral replication, etc.

  • It has many actions but leads to the prevention of viral replication
14
Q

Ribavirin Indications

A
  • HCV

- RSV

15
Q

Ribavirin SE

A

Severe hemolytic anemia

16
Q

Ribavirin Contraindications

A

Pregnancy

17
Q

Pegylated Interferon MOA

A

Stimulates host antiviral immunity

18
Q

What are the best drugs to use for HCV?

A

Direct Acting Antivirals

19
Q

What is the function of NS3/4A in HCV?

A

Viral protease to cleave translated proteins

20
Q

What is MOA of the DAA drugs?

A
  • Competitively inhibit viral protease

- Inhibit viral RNA polymerase, allosterically or via chain

21
Q

Entecavir MOA

A

Guanosine analog; inhibits viral polymerase

22
Q

Tenofovir MOA

A

Adenosine analog; inhibits viral polymerase

23
Q

Entecavir SE

A

Lactic acidosis with rebound hepatitis

24
Q

What type of influenza does amantidine work against?

A

Only type A influenza

25
Q

What are some of the SE of amantidine?

A

Anxiety, disorientation, headache

26
Q

What class are zanaminivir and oseltamivir?

A

Neuraminidase Inhibitors

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