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Q4 Pharm psych > Antipsych > Flashcards

Flashcards in Antipsych Deck (17)
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1
Q

Positive sxs of schizophrenia?

Caused by?

A

Hallucinations (site/sound)
Delusions
Disorganized speech/thought

Over-active DA path in limbic syst (mesolimbic)

2
Q

Negative sxs of schizophrenia?

Caused by?

A
Apathetic
Withdrawn
Anti-social
Unmotivated
Depressed

Under-active DA paths in front cortex (mesocortical)

3
Q

Cognitive impairment a/w schizophrenia?

A

Distracted

Memory loss

4
Q

Mesolimbic DA Pathway is?

Affects?

A

Ventral Tegmental Area (VTA) to limbic system

Emotion

5
Q

Mesocortical DA Pathway is?

Affects?

A

VTA to front cortex

Cognition, Emotion

6
Q

Nigrostriatal DA Pathway is?

Affects?

A

Substantia Nigra to striatum

Motor

7
Q

Tuberoinfundibular DA Pathway is?

Affects?

A

Hypothalmus to pituitary

Prolactin

8
Q

Extrapyramidial Symptoms (EPS) are?

Caused by?

A

Parkinson-like:
tremor, rocking, pacing, dystonia, rigidity, dyskinesia

DA Recp Antagonists blocking DA recps in nigrostriatal path ->
causes imbal of striatal DA/ACh

9
Q

Treat EPS sxs how?

A

anticholinergics (benztropine)

10
Q

Tardive Dyskinesia (TD) is?

A

uncontrolled mvmt of mouth/face,
from long-term tx,
U irreversible

11
Q

Neuroleptic Malignant Syndrome (NMS) is?

A

mm rigidity, very high fever, BP/HR changes

LIFE THREATENING

12
Q

NMS caused by?

A

DA D2 recp block in striatum and hypothalamus

13
Q

NMS tx?

A
Dantrolene (Dantrium)
DA agonist (bromocriptine)
14
Q

Antipsych drug interactions:

Anticholinergics?

Sedative/Hypnotics?

TCAs?

CYP450 inducers?

Antihypertensives?

A

Antichol: ↑ s/e (dry mouth, constip, etc)

Sed/Hyp: ↑ sedation

TCAs: seizures, cardiac

CYP450: carbamazepine, cimetidine, smoking

Antihyp: unpredictable

15
Q

Bipolar caused by?

U treated with?

A

Low GABAergic activity

Cobo of Li+, anticonvulsants and Zyprexa

16
Q

Li+ reabsorption?

A

PCT of kidney
Competes w/ Na+ for reab
Inhibits ADH -> cause Diabetes Insip

17
Q

Li+ drug interactions:

Antidep?

BZs/Anti-psych?

Diuretics?

NSAIDs?

Na+?

A

Antidep: ↑ mania

BZs/Anti-psych: safe

Diuretics: ∆ Li+ clearance

NSAIDs: ↑ Li+ toxicity (↑ uptake/↓ clearance)

Na+: ↓ [Li+], Li+ may cause ↓ Na+ reab and hypoNa+