ANTIPLATELET PHARMACOLOGY Flashcards Preview

PHARMA I > ANTIPLATELET PHARMACOLOGY > Flashcards

Flashcards in ANTIPLATELET PHARMACOLOGY Deck (12)
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1
Q

this is the major cause of morbidity and mortality in western societies with 500,000 deaths in the US each year

A

atherosclerosis

2
Q

this is the initiating event in the development of an acute MI

A

thrombus

3
Q

name this type of hemostasis…

vascular endothelium damage to platelet adhesion, activation and aggregation

A

primary hemostasis

4
Q

vascular sub endothelium collagen exposure affect primary hemostasis how?

A

stimulators of platelet activation

5
Q

stimulators of platelet aggregation?

A

thromboxane A2
ADP
serotonin

6
Q

name this type of hemostasis…

coagulation proteins to coagulation cascade

A

secondary hemostasis

7
Q

what are the classes of anti platelets?

A

cyclo oxygenate inhibitors

selective ADP inhibitors

8
Q

what are the two important cycle oxygenate inhibitors?

A

aspirin

NSAIDs

9
Q

MOA of what cyclo oxygenate inhibitors

irreversible inhibitor of platelet CO

duration of effect is the time span of the platelet (6-10 days)

A

aspirin

10
Q

MOA of what cyclo oxygenate inhibitors

reversible inhibitor of platelet CO

not useful clinically due to short duration

A

NSAIDs

11
Q

what are the important side effects of cycle oxygenate inhibitors?

A

tinnitus with high levels

12
Q

meds that increase risk of bleeding?

effect of methotrexate and valproic acid?

A

warfarin, NSAIDs

cause an increase in the dose

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