Antimalarials Flashcards Preview

Pharmacology > Antimalarials > Flashcards

Flashcards in Antimalarials Deck (10)
Loading flashcards...
1
Q

Quinidine has an extra benzene ring and is considered an acridine compound

A

FALSE
quinaCRINE
Quinidine is an anti arrhythmic

2
Q

Antimalarials Are all water soluble

A

T

3
Q

Half life of Hcq and CQ is 40-50 hours

A

False

40-50 days

4
Q

Antimalarials have the highest concentration in bone , skin, and fat and the lowest in the liver , spleen and kidney tissues

A

F

Vice versa

5
Q

No dosage adjustment is required in pt with mild to moderate renal function impairment

A

T

Only 20% of unchanged HCQ eliminated by the kidneys

6
Q

MoA antimalarials

A
1- light filtration 
2- immunosuppressive effects
3- anti inflammatory effects
4- antiviral effects
5- inh platelet aggregation
6-  anti proliferative effects
7- reduction in Lipid and VitD levels

LIIVPPD

7
Q

Metabolites of HCQ are desethylchloroquine and desethylhydroxychloroquine

A

T

8
Q

Pregnancy and lactation is a relative CI in antimalarials as crosses placenta and excreted into Breast milk

A

T

9
Q

When taking antimalarials , ophthalmologist testing should occur at baseline and every 1-2 y for first five years

A

T

10
Q

Most antimalarials are substituted 4-aminoquinolones

A

True