Antigen recognition by T cells Flashcards Preview

Basic Immunology- Module 1 > Antigen recognition by T cells > Flashcards

Flashcards in Antigen recognition by T cells Deck (18)
Loading flashcards...
1

How does the B cell receptor bind epitopes with high affinity?

through random somatic mutation and affinity maturation

2

How do T cell receptors bind complexes with moderate affinity?

random somatic mutation

3

What do B cell receptors bind?

conformational epitopes

4

What do T cell receptors bind?

peptide-MHC complexes

5

What is required for rearrangement of VDJ genes?

recombinase activating genes - RAG recombination system

6

Recombination of what genes creates the TCR alpha chain?

VJ

7

recombination of which genes creates the TCR beta chain?

VDJ

8

What area of the TCR is key for peptide:MHC recognition?

CDR3- determines specificty of hte TCR

9

What size of antigen can CD8 cells recognise?

8-9 amino acids long

10

What size of antigen can CD4 cells recognise?

variable length of peptide

11

What proteolytic enzymes are involved in antigen processing in the lysosyme?

cathepsins B, D, S, L

12

How is MHC class I II restricted antigen recognition imposed?

by the requirement of co-receptors e.g CD8 and CD4

13

What is the function of CD3 in the TCR?

doesn't have antigen specificty but is used in signalling

14

In what area of the BCR and TCR does VDJ recomination generate somatic diversity?

CDR3

15

What are hte CDR1/2 areas of the TCR or BCR generated from?

germline

16

What happens to the CDR1/2 regions in BCR?

hypermutated

17

What is a complementarity determing region?

loop of the receptor that makes contact with antigen

18

What is the function of MHC tetramers?

regaents that mimic binding of pMHC to the TCR (but fluorescent) with a higher affinity to characterise T cell s of a particular specificity