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Immunology > Antigen > Flashcards

Flashcards in Antigen Deck (15)
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1
Q

What is immunogen

A

Antigen that induces a subsequent immune response

2
Q

What is an epitope

A

Structure recognized by antibody

3
Q

Are B cell epitopes conformational or linear

A

usually conformational but can be both

4
Q

What’s a linear epitope

A

Structures recognized by an antibody or t-cell that are composed of a single linear segment of polypeptide chain

5
Q

What is foreignness

A

How different is antigen from the host. More foreignness= easier to be recognized by immune system

6
Q

Does size matter

A

the bigger it(antigen) is…the better the immune respose is

7
Q

What is a hapten

A

Low molecular weight compound (penicillin).
Cannot elicit an immune response.
Must be bound to larger molecule (carrier).
Changes the existing epitope or creates a new epitope

8
Q

How does chemical composition influence immunogens (what are best)

A

Proteins are the best > carbs > nucleic acids

9
Q

How does complexity influence immunoginisity

A

More complex= better immunogen. Glycoproteins > complex carbs

10
Q

What are conformational determinants

A

3D structure of immunogen. More complex = better immunogen

Conformational immunogens

11
Q

What is immunogenicity derived from

A

Genetics, Age, how it’s acquired (route, local environment, timing, dose, etc)

12
Q

can Antibody be an antigen

A

Yes, used in ELISA things

13
Q

What are isotypic epitopes

A

Epitopes derived from the C H chain that determines the isotype (anti-IgG) Used in ELISA

14
Q

What is immune complex glomerulonephritis

A

Excess Ab lodge in the basement membrane of the glomeruli

15
Q

What is an antigen

A

Foreign or endogenous substance recognized by immune system