Antifungals/Antiprotazoal Flashcards
Mechanism of amphotericin B
binds ergosterol (unique to fungi) forms membrane pores that allow leakage of electrolytes
Use of amphotericin B
serious, systemic mycoses
Crypto - w/wo flutocytosine for meningitis
Blasto, Histo, Candida, Mucor
Intrathecally for fungal meningitis
what electrolytes should you supplement with amphotericin B use?
K+ and Mg2+ because of altered renal tubule permeability
Toxicity of amphotericin B
fever/chills hypotension nephrotoxicity arrhythmias anemia IV phlebitis hydration decreases nephrototixicty liposomal amphotericin decreases toxicity
Mechanism of nystatin
same as amphotericin B
topical use only as too toxic for systemic use
Use of nystatin
“swish and swallow” for oral candidiasis (thrush); topical for diaper rash or vaginal candidiasis
Mechanism of flucytosine
inhibits DNA and RNA biosynthesis by conversion to 5-fluorouracil by cytosine deaminase
Use of flucytosine
systemic fungal infections (especially meningitis caused by cryptococcus) in combination with amphotericin B
Toxicity of flucytosine
bone marrow suppression
Name the azoles
clotrimazole, fluconazole, itraconazole, ketoconazole, miconazole, voriconazole
Mechanism of the azoles
inhibit fungal sterol (ergosterol) synthesis by inhibiting cytochrome p450 enzyme that converts lanosterol to ergosterol
Use of azoles
local and less serious systemic mycoses
Use of fluconzaole
chronic suppression of cryptococcal meningitis in AIDS patients and candidal infections of all types
Use of itraconazole
blastomycoses, coccidioides, histo
Use of clotrimazole and miconazole
topical fungal infections
