Antidiabetic Drugs III Flashcards
bile acid sequestrant
Colesevelam
AE of bile acid sequestrant
colesevelam
Constipation Nausea Dyspepsia Increase TAG levels Interfere with absorption of oral drugs
SGLT2 inhibitor
Canagliflozin
mechanism of SGLT2 inhibitor
Canagliflozin
SGLT2 responsible for the most glucose reabsorption –> inhibit it –> decreased glucose absorption, increased glucose excretion, and decreased blood glucose levels
AE of SGLT2 inhibitor
Canagliflozin
Genital and Urinary Tract Infection
Osmotic diuresis –> hypotension, volume depletion, increased creatinine levels, hyperkalemia, hypermagnesemia, hyperphosphatemia
contraindication of SGLT2 inhibitor
GFR less than 45ml/min/1.73 m2
drug usually given if metformin is contraindicated
Sulfonylurea
Pioglitazone
Sitagliptin
what determines if insulin would be given to a type II diabetic
person with high HbA1c level especially if greater than 8.5%
major cause of morbidity and mortality in diabetic patients
Cardiovascular Disease
drugs used for neuropathic pain in diabetics (for dystal symmetric polyneuropathy)
GAP DOVV
Gabapentin
Amitriptyline
Pregabalin
Duloxetine
Opioids
Venlafaxine
Valproate
gastroparesis can be treated with what
metoclopramide and erythromycin
DOC for preggo with diabetes
Regular human insulin: short acting insulin
mechanism of glucagon
works via Gs –> increase in cAMP –> release of glucose from liver
effect of glucagon on heart and SM
heart: potent inotropic and chronotropic effect without using beta receptor
SM: relaxation of intestine
uses of glucagon
GRaBS
Glucagon C peptide test (test for residual beta cell function in DM)
Radiology of Bowel (relax intestine)
Beta blocker poisoning
Severe Hypoglycemia
