Anticoagulant Agents Flashcards Preview

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Flashcards in Anticoagulant Agents Deck (14)
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1
Q

Heparin MOA

A

potentiates antithrombin III (inhibits conversion of fibrinogen to fibrin)

2
Q

Heparin Monitoring

A

PTT (in pts = intrinsic pathway)

3
Q

Heparin SEs

A

*Heparin induced thrombocytopenia (HIT)

4
Q

Heparin Antidote

A

Protamine Sulfate

5
Q

LMWH

A
  • Enoxaparin (Lovenox)

- Dalteparin (Fragmin)

6
Q

LMWH MOA

A
  • ***inactivates factor Xa

- potentiates antithrombin III (inhibits conversion of fibrinogen to fibrin)

7
Q

LMWH Monitoring

A

-none (longer 1/2 life = 12 hrs)

8
Q

LMWH SEs

A

-thrombocytopenia (< than UFH)

9
Q

LMWH CI/Cautions

A
  • Renal failure

- not as easily reversible as Heparin

10
Q

Thrombin Inhibitors

A
  • Dabigatran

- Argatroban

11
Q

Thrombin Inhibitors MOA

A

Directly inhibits thrombin

12
Q

Thrombin Inhibitors Indication

A

1st line tx for HIT

13
Q

Factor X Inhibitors

A
  • Fondaparinux
  • Rivaroxaban
  • Apixaban
14
Q

Factor X Inhibitors MOA

A

Selective factor Xa inhibitor