Antibiotics Flashcards Preview

RUSVM Bacteriology Gram Negatives > Antibiotics > Flashcards

Flashcards in Antibiotics Deck (14)
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0
Q

Disrupt cell membranes by binding to membrane phospholipids –> structural disorganization. Maybe nephro/neurotoxic

A

Polymixin B&E , topical

1
Q

Mainly against active growing gram positives, prevent cross linking of peptidoglycan chains so bad cell wall synthesis

A

Penicillin & cephalosporins

2
Q

Block 30S ribosomal activity against gram negative bacteria. Nephrotoxic and ototoxic

A

Aminoglycosides - Streptomycin & Neomycin

3
Q

Block 30S by not blocking tRNA binding

A

Tetracyclines : macrolides

4
Q

Block 50S ribosomal activity

A

Chloramphenicol

5
Q

Block 50S; Contraindicated in horses & neonates

A

Lincosamides

6
Q

Block 50S activity, mainly against gram positives and some mycoplasmal pathogens

A

Macrolides : erythromycin & tylosin

7
Q

Block DNA directed RNA polymerase, inhibits transcription, antimycobacterial ( use with erythromycin for R. Equi Tx)

A

Rifampins

8
Q

Block DNA gyrase, no DNA unwinding, no replication. Use for mastitis Tx

A

Novobiocin

9
Q

Blocks DNA gyrase, Tx of enteric infections and intracellular pathogens

A

Quinolones (enrofloxacin), nalidixic acid

10
Q

Block pathway of making folic acid

A

Sulfonamides

11
Q

Combines with enzyme dihydrofolate to block nucleic acid synthesis

A

Trimethoprim

12
Q

Antibiotic synergism - two pairs

A

Penicillins & Aminoglycosides (inhibit cell wall synthesis & allow aminoglycosides entry)
- Sulfonamides & Trimethoprim (inhibit frolic acid synthesis, work together)

13
Q

Antibiotic antagonism (one pair)

A

Penicillin & bacteriostatic antibiotics (penicillin acts in cell walls of growing bacteria, doesn’t work if growth stops)