ANTIARRYTHMIC DRUGS I Flashcards Preview

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Flashcards in ANTIARRYTHMIC DRUGS I Deck (25)
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1
Q

all antiarrhythmics are?

A

pro-arrhythmic and negative inotropic

2
Q

wolff-parkinson white syndrome is what kind of arrhythmia?

A

supra ventricular

3
Q

torsade de pointes is what kind of arrhythmia?

A

ventricular

4
Q

oldest most common less descriptive antiarrhythmic classification?

A

vaughn williams

5
Q

all the important class Ia drugs?

A

quinidine

disopyramide

6
Q

all the important class Ib drugs?

A

mexiletine

7
Q

all the important class Ic drugs?

A

flecainide

propafenone

8
Q

all the important class III drugs?

A

amiodarone
dronedarone
sotalol
dofetilide

9
Q

all the important class V drugs?

A

digoxin

10
Q

all class Ia drugs have the potential to cause?

A

Torsades de pointes

11
Q

main drug interaction of quinidine, a class Ia drug?

A

inhibits CYP2D6

12
Q

main considerations of quinidine?

A

increases AV nodal conduction

13
Q

disopyramide, a class Ia drug has these major side effects?

A

anticholinergic
heart failure
torsade’s
GI

14
Q

main consideration of disopyramide, a class Ia drug?

A

may be used in patients with hypertrophic cardiomyopathy

15
Q

mexiletine, a class Ib drug, has this main consideration?

A

not very effective as a single agent

16
Q

class Ic, a potent sodium channel blocker, has the most important effect on which phase?

affect on CV?

A

phase 0 of action potential (decreases its slope)

negative inotropy***
bradycardia
heart failure
heart block

17
Q

propafenone, a class Ic drug, has this major side effect?

A
metallic/bitter taste***
headache
negative inotropy 
cholestatic jaundice
heart block
18
Q

this class III drug is 1/3 less effective than amiodarone?

no iodine w/ a shortened half life of 14 hrs

A

dronedarone

19
Q

this beta blocker? has what class activity?

A

sotalol, second most used antiarrhythmic

20
Q

what is the major consideration of sotalol?

how is this eliminated?

A

torsades

renally eliminated

21
Q

this class III drug is a potassium channel blocker? and has what percent renal elimination?

A

dofetilide

80%

22
Q

what is significant about the QT interval of dofetilide, a class III drug?

major side effect?

A

determined before 1st dose

torsades

23
Q

this class V drug? has what type of elimination?

A

digoxin

P-gp elimination

24
Q

T/F, digoxin, a class V drug, does not convert patients out of AFIB?

A

T

25
Q

this drug is first line in most patient populations?

A

amiodarone

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