Anti-disrhythmic drugs Flashcards Preview

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Flashcards in Anti-disrhythmic drugs Deck (11)
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1
Q

VWS

Class 1a

A

Dysopyramide

Procainamide

2
Q

VWS Class 1 what target?
What use?
Side effects

A

Blocks Na+ channels
Ventricular dysrhythmias
CNS: Suppression, convulsions

3
Q

VWS

Class 1b

A

Lidocaine

4
Q

VWS

Class 1c

A

Flecainide

5
Q
VWS 
Class 2 
Target
Uses
Unwanted effects
A

B1 adrenoceptor anatagonists
Supraventricular and ventricular dysrhytmias
Unwanted effects:
Cold extremities, bronchoconstriction, vivid dreams, hypoglycaemia, precipitation of cardiac failure/heart block

6
Q

VWS Class 2 drugs

A

propranolol

atenolol

7
Q

More detail as how class 2 drugs work

A

↑Discharge rate of SA Node
↑automaticity in ventricular and atrial myocardia
Improved conduction through AV node
Blocks B1 adrenoceptor in: SA node, AV node, ventricular tissue
Reduces phase 4 depolarisation of SA and AV node, therefore slows sinus rhythm and slows conduction through AV node

8
Q

Antidysrhytmic uses of B1-adrenoceptor antagonists

A

Suppression of dysrhymias induced by:

Excessive catecholamine release
Increased tissue sensitivity to catecholamines

9
Q

Amiodarone
Class
Mechanism
Properties

A

Class III - blocks K+ channels, prolongs AP
Also Class I and IV as also blocks Na+ and Ca2+

V.lipoholic
large volume of distribution
weeks/months of oral dosing before steady state plasma concentration is reached
Half life long, 10-100 days

10
Q

Amiodarone uses
Route of admin
Side effects

A

-atrial flutter or AF
-Paroxysmal supraventricular tachycardia (e.g. in Wolff-Parkinson-White syndrome)
-VF and ventricular tachycardia
Side effects:
-Microcrystals in cornea - increased dazzle from lights
-Photoxic reactions from microcrystals in skin - black and green skin - UV light reaction with microcrystal deposits
-Thyroidtoxicosis or hypothyroidism
-Diffuse pulmonary alveolitis, pneumonia
-Bradycardia and conduction disturbance

11
Q
Class IV drugs 
Mechanism of action
2 examples 
Uses
Adverse effects
A

Verapamil, Diltiazem
Calcium channel blockers/calcium antagonists
Uses: PSVT, can reduce ventricular rate in AF
Adverse effects:
-can make dysrhythmias worse, dangerous in ventricular dysrhythmias and WFW syndrome
-Hypotension
-cardiodepression
-oedma
-AV node block
-headache
-constipation