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Q3 Pharm Cholinergics > ANS > Flashcards

Flashcards in ANS Deck (36)
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1
Q

ANS Parasymp fibers?

Release what neurotrans?

A

Long pre-gang from cranial and sacral:
release ACh

Short post-gang near organ:
release ACh

2
Q

ANS Symp fibers?

Release what neurotrans?

A

Short pre-gang in thoracic and lumbar:
release ACh

Long post-gang at target:
release NE

3
Q

ACh released by which fibers? (5)

A
All pre-gang
Parasymp post-gang
Symp to sweat glands
At adrenal medulla
Somatic to mm
4
Q

Norepi released by which fibers?

A

Symp post-gang (except sweat glands)

Adrenal medulla

5
Q

Dopamine released by?

A

renal vasculature

6
Q

5 steps in neurotrans fxn?

A

1) synthesis
2) storage
3) release
4) receptor interaction
5) inactivation

7
Q

ACh made how?

A

Choline + Acetyl CoA -> ChAT enz -> ACh

8
Q

ACh inactivated by?

A

acetylchoninesterase

9
Q

Adrenergic (epi) transmission cycle?

A

Tyrosine into terminal ->
∆ to DOPA then dopamine ->
∆ to NE ->
released to receptors

10
Q

DOPA synth blocked by?

A

metyrosine

11
Q

NE in vesicle depleted by?

A

reserpine

12
Q

NE re-uptake blocked by?

A

cocaine and TCAs

13
Q

NE release ↑ by?

A

amphetamines, tyramine

but only if terminal is intact

14
Q

NE metabolized by?

A

MAO and COMT

15
Q

Cholinergic receptors? (4)

A

M1: sweat glands, CNS
M2: heart, smooth mm, presynaptic
M3: exocrine, smooth mm, endothelium
Nicotinic: Na+ channel, Nn, Nm

16
Q

Cholinergic receptors controlled what:

M1
M2
M3

A

M1 and M3: Gq/11; PLC, IP3, DAG

M2: Gi; inhibits adenylyl cyclase

17
Q

Adrenergic receptors? (5)

A
α1: smooth mm, excitatory
α2: presynap terminals, some smooth mm
β1: heart
β2: heart, bronchioles, skeletal mm blood vessles
β3: fat cells (lypolysis)
18
Q

Adrenergic receptors control what:

α1
α2
all β

A

α1: Gq; PLC, IP3, DAG

α2: Gi; inhibits adenylyl cyclase

all β: Gs; stim adenylyl cyclase

19
Q

Dopamine receptors?

A

D1, D5: brain, vascular bed

D2, D3, D4: brain, other tissues

20
Q

Dopamine receptors controlled what:

D1, D5
D2, D3, D4

A

D1, D5: ↑ cAMP

D2, D3, D4: ↓ cAMP

21
Q

Down-Regluation is?

A

constant stim w/ agonist causes:

↑ destruction of receptors or
∆ in affinity which ↓ receptor response

22
Q

Up-Regulation is?

A

lack of stim causes:

# of receptors to ↑ or
response of receptor to ↑
23
Q

Parasymp response in:

heart, bv, lungs

A

↓ HR and AV conduction (M2)

bronchoconstriction (M3)

24
Q

Symp response in:

heart, bv, lungs

A

↑ HR, AV conduction and contractility (β1)
bronchodilation (β2)
bv constriction (α1)

25
Q

Parasymp response in:

glands, eyes

A

miosis, accommodation
↑ mucus, salivation, lacrimation
(M3)

26
Q

Symp response in:

glands, eyes

A

mydriasis, vasoconstriction, salivation (α)

sweating (M1)

27
Q

Parasymp response in:

GI

A

↑ hydrochloric acid secretion,
↑ motility,
relax sphincters
(M3)

28
Q

Symp response in:

GI

A

glycogenolysis (β2),

↓ motility (α2, β2)

29
Q

Parasymp response in:

GU

A

contract bladder,
relax sphincters,
promote erection
(M3)

30
Q

Symp response in:

GU

A

renin secretion (β1),
relax bladder and uterus (β2),
contract sphincters, ejaculation (α1)

31
Q

Baroreceptor reflex initiated by?

A

NE release:
α causes vasoconstriction
β1 ↑ HR/contractility
= ↑ arterial pressure

32
Q

Baroreceptor response to ↑ arterial pressure in aortic arch?

A

↑ afferent impulse to medulla:

↓ symp -> vasodialtion

↑ parasymp -> ACh release -> ↓ HR and CO

33
Q

Muscarinic receptors in ciliary mm do what?

A

constrict = lens rounds

34
Q

Pupil size controlled how?

A

Symp stim of α1 receptor in iris radial mm = contract to dilate pupil

Parasym stim of M3 receptor in iris circular mm = contract to constrict pupil

35
Q

Summary of eye: Muscarinic Agonists do?

A

contract circular mm (constriction),
contract ciliary mm (accommodation),
↑ outflow aqueous humor into canal of Schlemm,
↓ intraocular pressure

36
Q

Summary of eye: Adrenergics do?

A

contract radial mm (dilation),
↑ prodxn aqueous humor,
↑ intraocular pressure