Anemia of CKD/ESRD Flashcards Preview

Hematology, oncology > Anemia of CKD/ESRD > Flashcards

Flashcards in Anemia of CKD/ESRD Deck (3)
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1
Q

Why don’t you measure EPO?

A

Not usable as an indicator of a renal source of the anemia, because, in kidney disease, there is ‘relative erythropoietin deficiency,’ that is, an inappropriate rise in erythropoietin levels for the severity of anemia.

2
Q

Why EPO has fallen out of favor among hematologists

A
  • increased risk of mortality and recurrent HF
3
Q

Other main mechanism of anemia in CKD

A
  • secondary hyperparathyroidism (results in resistance to EPO. also shortens RBC survival because high levels of PTH acts as a uremic substance)
  • parathyroidectomy has been shown to reduce requirements for postoperative ESAs

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