Androgens Flashcards Preview

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Flashcards in Androgens Deck (18)
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1
Q

What is the most potent androgen?

A

DHT

2
Q

What are some actions of androgens?

A
  • Promotes spermatogenesis
  • Promotes lean body mass and skeletal muscle growth
  • Reduces fat mass
  • Growth of larynx
  • Closure of the epiphyseal plates
  • Puberty in females
  • Erythropoiesis
3
Q

What is the effect of androgens on clotting factor?

A

Decreases synthesis of clotting factors

4
Q

What is the effect of estrogens on clotting factor?

A

Increases synthesis

5
Q

What are the consequences of decreased androgens in males?

A
  • Decreased libido
  • Decreased muscle mass
  • Decreased axillary and pubic hair
  • Anemia and osteoporosis
6
Q

What are the indications of androgens?

A
  • HRT in hypogonadism
  • Induction of puberty
  • Osteoporosis in males
7
Q

What are some contraindications of androgens as HRT?

A
  • Breast cancer in men
  • Prostate cancer
  • Pregnancy
8
Q

Flutamide MOA

A

Competitive antagonist of DHT and testosterone binding

9
Q

Flutamide Indications

A
  • Metastatic prostate cancer

- BPH

10
Q

Flutamide SE

A
  • Hepatotoxicity
  • Diarrhea/Nausea
  • Hematopoietic Diseases
11
Q

Flutamide Contraindication

A

Severe hepatic impairment

12
Q

Leuprolide MOA

A

GnRH agonist

13
Q

Spironolactone MOA

A

Inhibition of DHT and T binding

*Also is an aldosterone receptor antagonist

14
Q

Spironolactone Indications

A
  • Hirsutism
  • HTN
  • Acne
  • Edema from CHF
  • Hypokalemia
15
Q

Spironolactone Contraindications

A
  • Anuria
  • Hyperkalemia
  • Renal insufficiency
16
Q

Finasteride MOA

A

Selective inhibition of type II 5-alpha reductase

17
Q

Finasteride Indications

A
  • BPH (very effective)

- Androgenic alopecia

18
Q

Finasteride Contraindications

A

Pregnancy

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