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PHARMA I > AMIODORONE > Flashcards

Flashcards in AMIODORONE Deck (8)
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1
Q

amiodarone is what class drug?

A
class III
potassium channel blocker
2
Q

notable characteristic of amiodarone?

A

most effective antiarrhythmic action

3
Q

this class III drug increases the refractory period, but this drug and sotalol decreases AV nodal conduction?

A

amiodarone

4
Q

major side effects of amiodarone?

A
has a wide range body of distribution, except kidney
pulmonary toxicity
thyroid toxicity
hepatoxicity
cardiac toxicity
Neurologic
ocular(corneal deposits)
GI (N/V)
5
Q

Amiodarone incidence of fatality?

A

10% fatalities

6
Q

amiodarone inhibits what enzyme?

A

CYP3A4, so cisapride, theophylline, statins

7
Q

digoxin levels
warfarin effects
procainamide levels

these are increased or decreased by amiodarone?

A

increased

8
Q

the drug interactions, specifically the pharmacodynamics affects what meds?

A

calcium channel blockers

beta blockers

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