Acute lymphoblastic leukaemia Flashcards Preview

Year 3 : haem conditions > Acute lymphoblastic leukaemia > Flashcards

Flashcards in Acute lymphoblastic leukaemia Deck (5)
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1
Q

definition of ALL?

A

malignancy of the bone marrow and blood characterised by the proliferation of lymphoblasts

2
Q

epidemiology of ALL? very important

A
  • MOST COMMON malignancy of CHILDHOOD
  • Peak incidence: 2-5 yrs old
  • Boys are more affected than girls
3
Q

symptoms and signs of ALL?

A
o	Anaemia 
-	Fatigue
-	Dyspnoea
-	Pallor
-	Soft systolic murmur 
o	Thrombocytopenia
-	spontaneous bruising
-	bleeding gums
-	menorrhagia
o	Neutropoenia 
-	frequent and severe infections
•	Symptoms and signs of Organ Infiltration: 
o	Tender bones  
o	Splenomegaly 
o	Hepatomegaly
4
Q

initial investigations?

A

• Bloods
o FBC - normochromic normocytic anaemia, low platelets, variable WCC
• Blood Film –
o Abundant lymphoblasts

5
Q

confirming diagnosis for ALL?

A

• Bone Marrow Aspirate

lymphoblasts will be present