Flashcards in Acute Leukemias Deck (44)
ALL cases more frequently involve _____ cells (~80%).
__-ALL is more commonly seen in adolescents and young adults.
__-ALL is more commonly seen in children.
__-ALL is more commonly seen in men than women
__-ALL is more likely to present with a large mediastinal mass.
B-ALL has a ______ prognosis than T-ALL.
B-ALL is more commonly seen in _____ (demographic).
Cytogenetic abnormalities associated with AML due to CBFB-MYH11
inv(16)(p13.1;q22) or t(16;16)(p13.1;q22)
Cytogenetic abnormality associated with a poor prognosis AML
Cytogenetic abnormality associated with AML due to RNX1-RNX1T1
Cytogenetic abnormality associated with AML with megakaryoblastic differentiation
Cytogenetic abnormality associated with APML
Cytogenetic abnormality most often seen in infants with Down Syndrome
Cytogenetic finding associated with AML with monocytic differentiation
Cytogenetic finding associated with B-ALL in neonates and young infants
Cytogenetic finding associated with the worst prognosis of any ALL
Cytogenetic finding with B-ALL with a very favorable prognosis
Findings to diagnose AML (2)
Myeloblasts >20% of nucleated cells in marrow or peripheral blood, cytogenetic findings
Fused azurophilic granules that form small stick-like structures in the cytoplasm
Genes associated with AML cases seen in younger patients with relatively good prognosis?
How is ALL prognosis affected by age?
Worst in infants, older children, or adults
How is ALL prognosis affected by chromosome ploidy?
Hyperdiploidy is associated with better prognosis
How is ALL prognosis affected by response to therapy?
Slow response is worse prognosis
How is ALL prognosis affected by T vs. B ALL?
B-ALL has better prognosis
How is ALL prognosis affected by WBC count?
Worse for higher count
Molecular markers currently used to predict prognosis in patients with AML with normal karyotype (3)
FLT3 ITD, NPM1, CEBPA
Negative prognostic factor associated with normal karyotype AML
Potential complication of t(15;17)(q22;q22)
Prognosis of t-AML