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Flashcards in Acute Leukemias Deck (44)
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1

ALL cases more frequently involve _____ cells (~80%).

B

2

__-ALL is more commonly seen in adolescents and young adults.

T

3

__-ALL is more commonly seen in children.

B

4

__-ALL is more commonly seen in men than women

T

5

__-ALL is more likely to present with a large mediastinal mass.

T

6

B-ALL has a ______ prognosis than T-ALL.

better

7

B-ALL is more commonly seen in _____ (demographic).

children

8

Cytogenetic abnormalities associated with AML due to CBFB-MYH11

inv(16)(p13.1;q22) or t(16;16)(p13.1;q22)

9

Cytogenetic abnormality associated with a poor prognosis AML

11q23 MLL

10

Cytogenetic abnormality associated with AML due to RNX1-RNX1T1

t(8;22)(q22;q22)

11

Cytogenetic abnormality associated with AML with megakaryoblastic differentiation

t(1;22)(p13;q13), RBM15-MKL1

12

Cytogenetic abnormality associated with APML

t(15;17)(q22q22)

13

Cytogenetic abnormality most often seen in infants with Down Syndrome

t(1;22)(p13;q13), RBM15-MKL1

14

Cytogenetic finding associated with AML with monocytic differentiation

11q23 MLL

15

Cytogenetic finding associated with B-ALL in neonates and young infants

11q23 MLL

16

Cytogenetic finding associated with the worst prognosis of any ALL

T(9;22)(q34;q11.2), BCR-ABL

17

Cytogenetic finding with B-ALL with a very favorable prognosis

t(12;21)(p13;q22), ETV6-RUNX1

18

Findings to diagnose AML (2)

Myeloblasts >20% of nucleated cells in marrow or peripheral blood, cytogenetic findings

19

Fused azurophilic granules that form small stick-like structures in the cytoplasm

Auer Rods

20

Genes associated with AML cases seen in younger patients with relatively good prognosis?

RNX1, CBFB

21

How is ALL prognosis affected by age?

Worst in infants, older children, or adults

22

How is ALL prognosis affected by chromosome ploidy?

Hyperdiploidy is associated with better prognosis

23

How is ALL prognosis affected by response to therapy?

Slow response is worse prognosis

24

How is ALL prognosis affected by T vs. B ALL?

B-ALL has better prognosis

25

How is ALL prognosis affected by WBC count?

Worse for higher count

26

Molecular markers currently used to predict prognosis in patients with AML with normal karyotype (3)

FLT3 ITD, NPM1, CEBPA

27

Negative prognostic factor associated with normal karyotype AML

FLT3 ITD

28

Potential complication of t(15;17)(q22;q22)

DIC

29

Prognosis of t-AML

Very poor

30

T-ALL has a _____ prognosis than B-ALL.

worse