Acute Leukemias Flashcards Preview

Lindsey's Blood and Lymph Unit III > Acute Leukemias > Flashcards

Flashcards in Acute Leukemias Deck (93)
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53

The leukemic cells themselves can cause _____ or _____ problems.

hyperviscosity; thrombotic problems

55

B-ALL with abnormalities of 11q23 MLL has a ____ prognosis.

poor

57

B-lymphoblasts express ____, ____, and/or ____.

CD19, CD22, CD79a

59

What has the worst prognosis of all ALLs?

Ph+ ALL

61

What is a solid mass malignancy of precursor lymphoid cells called?

lymphoblasic lymphoma (LBL)

63

In adults, ____ has a remission rate of 60-80% and cure rates of less than 50%.

ALL

64

AML with inv(16) or t(16;16) CBFB-MYH11 is notable bc of the presence of ____ with _____, called _____.

immature eosinophils; abnormal basophilic granules; baso esos

65

Why does the t(8;21) cause problems?

RUNX1 and CBF genes are blocked, so blood cells can't differentiate

66

APL accounts for ____% of AML, and is diagnosed when _____ is found.

5-10; t(15;17)

67

What does FLT3 ITD indicate?

negative AML,NOS

69

T-ALL occurs more commonly in ____ and ____.

males; adolescents and young adults

71

What is the incidence of ALL?

1-5:100,000

72

What antigens are only seen on immature T-cells?

CD99; CD1a

73

T-lymphoblasts express ____, ____, ____, ____, ____, ____, and/or _____.

CD2, CD3, CD7, CD4, CD8, CD99, CD1a

74

About 50% of all AML cases have a normal karyotype and are called ____.

AML-NOS (not otherwise specified)

75

ALL is divided into ____ and _____.

B-lymphoblastic ALL (B-ALL); T-lymphoblastic ALL (T-ALL)

75

The gene fusion in APL fuses the retinoic acid receptor-alpha (RARA) gene to another, so _____ is blocked.

differentiation

77

What do the cells look like in APL?

promyelocytes; hypergranular; Auer rods

78

What causes the s/s of acute leukemia?

loss of normal hematopoietic elements and blood cells

79

T-ALL more frequently occurs in ____.

adolescents and young adults

80

What is RUNX1?

a gene encoding for the alpha unit of core binding factor (CBF), a transcription factor needed for hematopoiesis

81

B-ALL with abnormalities of 11q23 MLL is frequently seen in _____.

neonates and young infants

82

Name 5 risk factors for acute leukemia.

1. chemo (esp of DNA alkylating agents or topo inhibitors) 2. tobacco smoke 3. ionizing radiation 4. benzene exposure 5. genetic syndromes (Down, Bloom, Fanconi anemia, AT)

83

What do Auer rods indicate?

that the cell is a myeloblast

84

In ____, ALL has a remission rate of 60-80% and cure rates of less than 50%.

adults

86

___ has a good prognosis in children; the complete remission rate is 95% and cure rates are about 80%.

ALL

87

In monocytic differentiation AML, the leukemic cells can express monocytic antigens ____ and ____.

CD64, CD14

88

____accounts for 10-20% of AML cases and has a very poor prognosis.

t-AML

89

What unique antigens does a myeloblast express?

CD34, CD117 (C-kit), myeloperoxidase, CD33, CD13

90

t-AML 2a to alkylating agents or radation usually have a latency period of ___ and has a karyotype showing ____.

2-8 years; whole or partial loss of chromosome 5 and/or 7